Carotid Imaging for Secondary Stroke Prevention in Routine Practice

Abstract

Carotid imaging is key to effective secondary stroke prevention. It is commonly performed, but is a rather specialist procedure requiring regular practice to maintain acceptable accuracy. Previously the domain of the neuroradiologist, noninvasive carotid imaging is now widely practiced in general departments where specialist knowledge of anatomy and intracranial disorders may be less available. Noninvasive imaging is largely replacing intraarterial angiography in the assessment of carotid stenosis in most centres because the accuracy is perceived to be sufficient. However, effective stroke prevention needs to be delivered rapidly, guided by imaging tests that are used with an understanding of their limitations and accuracy. This review will discuss currently available imaging methods, their advantages and disadvantages, difficulties in determining their accuracy, current estimates of accuracy and gaps in knowledge. Introduction: Stroke is common, has a poor outcome, and treatment must be delivered quickly. Many pharmacological acute stroke treatments have failed, reinforcing the need for effective prevention. There has been extensive testing of many pharmacological secondary prevention treatments and most of the ‘positive’ stroke trials have been in secondary prevention of ischaemic stroke. The surgical procedures for stroke prevention, carotid endarterectomy and angioplasty, have also been subjected to far closer scrutiny in large randomised-controlled trials than almost any other surgical or interventional radiological procedures. However, it is unfortunate that much of the focus of secondary stroke prevention has been on drug mechanisms, or surgery vs. endovascular methods, rather than on how to identify accurately and quickly the right patients for each intervention. Thus, until fairly recently ( 1 , 2 ), the need for very rapid initiation of medical and surgical interventions in patients whose carotid stenosis has been accurately diagnosed by imaging ( 3 ), and the service modifications required to deliver this ( 4 ), have largely been overlooked.