Affiliation:
1. Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA
2. Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA
3. Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas USA
Abstract
SummaryTargeted therapy development for acute myeloid leukaemia (AML) requires an understanding of specific expression profiles. We collected flow cytometry data on 901 AML patients and recorded aberrant CD7 expression on leukaemic blasts. 263 (29.2%) had blasts positive for CD7. CD7+ AML was more likely to be adverse risk (64.6% vs. 55.6%, p = 0.0074) and less likely to be favourable risk (15.2% vs. 24.1%, p = 0.0074) by European LeukemiaNet 2022 criteria. Overall survival was inferior (11.9 [95% CI, 9.7–15.9] vs. 19.0 months [95% CI, 16.1–23.0], p = 0.0174). At relapse, 30.4% lost and 19.0% gained CD7, suggesting moderate instability over time.