Characterization of AQX-1125, a small-molecule SHIP1 activator

Author:

Stenton Grant R1,Mackenzie Lloyd F1,Tam Patrick1,Cross Jennifer L1,Harwig Curtis1,Raymond Jeffrey1,Toews Judy1,Chernoff David1,MacRury Thomas1,Szabo Csaba1

Affiliation:

1. Aquinox Pharmaceuticals Inc.; Richmond; BC; Canada

Publisher

Wiley

Subject

Pharmacology

Reference30 articles.

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2. Expression of lung vascular and airway ICAM-1 after exposure to bacterial lipopolysaccharide;Beck-Schimmer;Am J Respir Cell Mol Biol,1997

3. PPAR-gamma agonists as therapy for diseases involving airway neutrophilia;Birrell;Eur Respir J,2004

4. MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4;Cekic;J Immunol,2011

5. SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo;Haddon;J Immunol,2009

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