Vascular imaging findings in retinopathy of prematurity

Author:

Rowe Lucas W.1ORCID,Belamkar Aditya1ORCID,Antman Gal234,Hajrasouliha Amir R.1ORCID,Harris Alon2ORCID

Affiliation:

1. Department of Ophthalmology, Glick Eye Institute Indiana University School of Medicine Indianapolis Indiana USA

2. Department of Ophthalmology Icahn School of Medicine at Mount Sinai Hospital New York New York USA

3. Department of Ophthalmology Rabin Medical Center Petach Tikva Israel

4. Faculty of Medicine Tel Aviv University Tel Aviv Israel

Abstract

AbstractRetinopathy of prematurity (ROP) is a vascular disease among preterm infants involving incomplete or abnormal retinal vascularization and is a leading cause of preventable blindness globally. Measurements of ocular blood flow originating from a variety of imaging modalities, including colour Doppler imaging (CDI), fluorescein angiography (FA) and ocular coherence tomography angiography (OCTA), have been associated with changes in ROP patients. Herein, we discuss and summarize the relevant current literature on vascular imaging and ROP reviewed through December 2022. Differences in vascular imaging parameters between ROP patients and healthy controls are reviewed and summarized. The available data identify significantly increased peak systolic velocity (PSV) in the central retinal artery and ophthalmic artery as measured by CDI, increased vascular tortuosity as measured by FA, smaller foveal avascular zone (FAZ) as measured by FA and OCTA, and increased foveal vessel density (VD) and reduced parafoveal VD as measured by OCTA in ROP patients compared with controls. None of the above findings appear to reliably correlate with visual acuity. The studies currently available, however, are inconclusive and lack robust longitudinal data. Vascular imaging demonstrates the potential to aid in the diagnosis, management and monitoring of ROP, alongside retinal examination via indirect ophthalmoscopy and fundus photography.

Publisher

Wiley

Subject

Ophthalmology,General Medicine

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