Collaboration for Evidence‐based Practice and Research in Anaesthesia (CEPRA): A consortium initiative for perioperative research

Author:

Nørskov Anders Kehlet12ORCID,Jakobsen Janus Christian34,Afshari Arash56,Bisgaard Jannie78,Geisler Anja16ORCID,Hägi‐Pedersen Daniel69,Lange Kai Henrik Wiborg26,Lundstrøm Lars Hyldborg26ORCID,Lunn Troels Haxholdt10,Maagaard Mathias1,Møller Ann Merete61112,Nedergaard Helene Korvenius413ORCID,Nikolajsen Lone1415,Olsen Markus Harboe316,Juhl‐Olsen Peter17,Rasmussen Bodil Steen78ORCID,Vested Matias18ORCID,Vester‐Andersen Morten611ORCID,Wikkelsø Anne19ORCID,Mathiesen Ole16,

Affiliation:

1. Centre for Anaesthesiological Research, Department of Anaesthesiology Zealand University Hospital Køge Denmark

2. Department of Anaesthesiology Copenhagen University Hospital – North Zealand Hillerød Denmark

3. Copenhagen Trial Unit, Centre for Clinical Intervention Research Copenhagen University Hospital – Rigshospitalet Copenhagen Denmark

4. Department of Regional Health Research, The Faculty of Health Sciences University of Southern Denmark Odense Denmark

5. Department of Paediatric and Obstetric Anaesthesia, Juliane Marie Centre Copenhagen University Hospital – Rigshospitalet Copenhagen Denmark

6. Department of Clinical Medicine Copenhagen University Copenhagen Denmark

7. Department of Anaesthesiology and Intensive Care Aalborg University Hospital Aalborg Denmark

8. Department of Clinical Medicine, Faculty of Medicine Aalborg University Aalborg Denmark

9. Research Centre of Anaesthesiology and Intensive Care Medicine, Department of Anaesthesiology Næstved‐Slagelse‐Ringsted Hospital Slagelse Denmark

10. Department of Anaesthesia and Intensive Care Copenhagen University Hospital ‐ Bispebjerg and Frederiksberg Copenhagen Denmark

11. Herlev Anaesthesia Critical and Emergency Care Science Unit, Department of Anaesthesiology Copenhagen University Hospital – Herlev and Gentofte Herlev Denmark

12. Cochrane Anaesthesia Group and Cochrane Emergency and Critical Care Group Copenhagen Denmark

13. Department of Anaesthesiology Intensive Care University Hospital of Southern Denmark Kolding Denmark

14. Department of Anaesthesiology and Intensive Care Aarhus University Hospital Aarhus Denmark

15. Department of Clinical Medicine Aarhus University Aarhus Denmark

16. Department of Neuroanaesthesiology, The Neuroscience Centre Copenhagen University Hospital – Rigshospitalet Copenhagen Denmark

17. Department of Cardiothoracic‐ and Vascular Surgery, Anaesthesia Section Aarhus University Hospital Aarhus Denmark

18. Department of Anaesthesia, Centre of Head and Orthopedics Copenhagen University Hospital – Rigshospitalet Copenhagen Denmark

19. Department of Anaesthesia and Intensive Care Medicine Zealand University Hospital Roskilde Denmark

Abstract

AbstractEvidence in perioperative care is insufficient. There is an urgent need for large perioperative research programmes, including pragmatic randomised trials, testing daily clinical treatments and unanswered question, thereby providing solid evidence for effects of interventions given to a large and growing number of patients undergoing surgery and anaesthesia. This may be achieved through large collaborations. Collaboration for Evidence‐based Practice and Research in Anaesthesia (CEPRA) is a novel collaborative research network founded to pursue evidence‐based answers to major clinical questions in perioperative medicine. The aims of CEPRA are to (1) improve clinical treatment and outcomes and optimise the use of resources for patients undergoing anaesthesia and perioperative care, and (2) disseminate results and inform caretakers, patients and relatives, and policymakers of evidence‐based treatments in anaesthesia and perioperative medicine. CEPRA is inclusive in its concept. We aim to extend our collaboration with all relevant clinical collaborators and patient associations and representatives. Although initiated in Denmark, CEPRA seeks to develop an international network infrastructure, for example, with other Nordic countries. The work of CEPRA will follow the highest methodological standards. The organisation aims to structure and optimise any element of the research collaboration to reduce economic costs and harness benefits from well‐functioning research infrastructure. This includes successive continuation of trials, harmonisation of outcomes, and alignment of data management systems. This paper presents the initiation and visions of the CEPRA network. CEPRA aims to be inclusive, patient‐focused, methodologically sound, and to optimise all aspects of research logistics. This will translate into faster research conduct, reliable results, and accelerated clinical implementation of results, thereby benefiting millions of patients whilst being cost and labour‐saving.

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine,General Medicine

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