Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation

Author:

Wu Zhuang1,Li Linlang1,Zheng Long-Tai1,Xu Zhihong2,Guo Lin1,Zhen Xuechu1

Affiliation:

1. Jiangsu Key laboratory of Translational Research and Therapy for Neuropsychiatric-disorders & Department of Pharmacology, College of Pharmaceutical Sciences; Soochow University; Suzhou Jiangsu China

2. Jiangsu Huayi Technology Co; Changshu Jiangsu China

Funder

National Science Foundation of China

National Basic Research Plan (973) of the Ministry of Science and Technology of China

Ministry of Education

Priority Academic Program Development of Jiangsu Higher Education Institutes

Jiangsu Key Laboratory

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Reference44 articles.

1. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids;Baulieu;Proc. Natl Acad. Sci. USA,1998

2. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures;Bhat;J. Neurosci.,1998

3. Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotection;Bhuiyan;Expert Opin. Ther. Targets,2011

4. Microglial phagocytosis of live neurons;Brown;Nat. Rev. Neurosci.,2014

5. Chinese-National-Research-Council 2006 The Guidelines for the Care and Use of Laboratory Animals http://www.nsfc.gov.cn/nsfc/cen/pfzl/pufanew/20110801_02.pdf

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