Association between the skin microbiome and lichen striatus hypopigmentation: Cutibacterium acnes as a potential cause

Abstract

AbstractBackgroundLichen striatus (LS) is an acquired skin disorder with a linear pattern along Blaschko's lines. It commonly occurs in childhood, and the lesions spontaneously regress within several months.ObjectivesAlthough up to 50% of LS cases exhibit hypopigmentation that can persist for several months to years, it is unknown why LS is associated with such a high incidence of hypopigmentation compared to other inflammatory skin diseases. Therefore, this study aimed to analyse the differences in the skin microbiome between LS patients with and without hypopigmentation.MethodsDifferences in skin microbiome were analysed using whole genome sequencing of skin biopsies and subsequent bioinformatics analyses.ResultsSome microbes commonly found in hypopigmented skin disorders, including Cutibacterium acnes, were more abundant in patients with LS showing hypopigmentation than in those not showing hypopigmentation.ConclusionsThe skin microbiota may be involved in the development of hypopigmentation in LS and may be considered a treatment target to reduce LS duration and hypopigmentation.