Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it
Author:
Affiliation:
1. School of Chemistry; The University of Manchester; UK
2. Manchester Institute of Biotechnology; The University of Manchester; UK
Publisher
Wiley
Subject
Cell Biology,Molecular Biology,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/febs.12268/fullpdf
Reference439 articles.
1. Studies on the activity of hydrazine derivatives of isonicotinic acid in the experimental tuberculosis of mice;Grunberg;Q Bull Sea View Hosp,1952
2. The discovery of antidepressants: a winding path;Pletscher;Experientia,1991
3. Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid;Mdluli;Science,1998
4. Genotype:phenotype mapping: genes as computer programs;Kell;Trends Genet,2002
5. Drug discovery: a historical perspective;Drews;Science,2000
Cited by 97 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects;International Journal of Molecular Sciences;2024-08-21
2. Expanding Predictive Capacities in Toxicology: Insights from Hackathon-Enhanced Data and Model Aggregation;Molecules;2024-04-17
3. Medical Applications of Systems Biology;Systems Biology Approaches: Prevention, Diagnosis, and Understanding Mechanisms of Complex Diseases;2024
4. Expanding Diterpene Complexity and Diversity via Photoinduced Ring Distortions;ChemPlusChem;2023-12-15
5. Optimizing assays of zebrafish larvae swimming performance for drug discovery;Expert Opinion on Drug Discovery;2023-05-15
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3