Tetrahedral framework nucleic acids‐based delivery of microRNA‐155 alleviates intervertebral disc degeneration through targeting Bcl‐2/Bax apoptosis pathway

Author:

Li Zhuhai12,Tang Yuanlin3,Wang Lihang14,Wang Kai1,Huang Shishu1ORCID,Chen Yu3

Affiliation:

1. Department of Orthopedic Surgery and Orthopedic Research Institute West China Hospital, Sichuan University Chengdu China

2. Department of Spine Surgery The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China

3. State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu China

4. Department of Spine Surgery Beijing Jishuitan Hospital Guizhou Hospital Guiyang China

Abstract

AbstractIntervertebral disc degeneration (IDD) is one of the most common causes of chronic low back pain, which does great harm to patients' life quality. At present, the existing treatment options are mostly aimed at relieving symptoms, but the long‐term efficacy is not ideal. Tetrahedral framework nucleic acids (tFNAs) are regarded as a type of nanomaterial with excellent biosafety and prominent performance in anti‐apoptosis and anti‐inflammation. MicroRNA155 is a non‐coding RNA involved in various biological processes such as cell proliferation and apoptosis. In this study, a complex named TR155 was designed and synthesised with microRNA155 attached to the vertex of tFNAs, and its effects on the nucleus pulposus cells of intervertebral discs were evaluated both in vitro and in vivo. The experimental results showed that TR155 was able to alleviate the degeneration of intervertebral disc tissue and inhibit nucleus pulposus cell apoptosis via Bcl‐2/Bax pathway, indicating its potential to be a promising option for the treatment of IDD.

Funder

Natural Science Foundation of Guangxi Zhuang Autonomous Region

Natural Science Foundation of Sichuan Province

Science and Technology Department of Sichuan Province

Publisher

Wiley

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