A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of theKCNE1gene-Reference-Cited by-同舟云学术

A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of theKCNE1gene

Published:2016-05-19 Issue:12 Volume:173 Page:2046-2061
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:British Journal of Pharmacology

Author:

Major Péter¹,Baczkó István²,Hiripi László¹,Odening Katja E.³,Juhász Viktor²,Kohajda Zsófia²,Horváth András²,Seprényi György⁴,Kovács Mária²,Virág László²,Jost Norbert²⁵,Prorok János²,Ördög Balázs²,Doleschall Zoltán⁶,Nattel Stanley⁷⁸⁹,Varró András²⁵,Bősze Zsuzsanna¹

Affiliation:

1. Rabbit Genome and Biomodel Group; NARIC - Agricultural Biotechnology Institute; Gödöllő Hungary

2. Department of Pharmacology & Pharmacotherapy; University of Szeged; Szeged Hungary

3. Department of Cardiology and Angiology I; Heart Center University of Freiburg; Freiburg Germany

4. Department of Biology; University of Szeged; Szeged Hungary

5. MTA-SZTE Research Group of Cardiovascular Pharmacology; Hungarian Academy of Sciences; Szeged Hungary

6. Department of Pathogenetics; National Institute of Oncology; Budapest Hungary

7. Department of Medicine, Montreal Heart Institute; Université de Montréal; Canada

8. Department of Pharmacology and Therapeutics; McGill University; Montréal Canada

9. Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine; University Duisburg-Essen; Essen Germany

Publisher

Wiley

Subject

Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.13500/fullpdf

Reference66 articles.

1. Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism;Abbott;FASEB J,2002

2. The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels;Alexander;Br J Pharmacol,2015

3. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death;Atiga;J Cardiovasc Electrophysiol,1998

4. Anatomical and molecular mapping of the left and right ventricular His-Purkinje conduction networks;Atkinson;J Mol Cell Cardiol,2011

5. K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current;Barhanin;Nature,1996

Cited by 37 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models;Scientific Reports;2023-09-29

2. Historical perspective and recent progress in cardiac ion channelopathies research and clinical practice in Hong Kong;International Journal of Arrhythmia;2023-05-01

3. ActionPytential: An open source tool for analyzing and visualizing cardiac action potential data;Heliyon;2023-03

4. Animal Transgenesis and Cloning: Combined Development and Future Perspectives;Methods in Molecular Biology;2023

5. A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5;Pharmaceuticals;2022-12-13