The risks of breast and ovarian cancer associated with the Ashkenazi Jewish founder allele BRCA2 6174delT-Reference-Cited by-同舟云学术

The risks of breast and ovarian cancer associated with the Ashkenazi Jewish founder allele BRCA2 6174delT

Published:2022-01-26 Issue:3 Volume:101 Page:317-323
ISSN:0009-9163
Container-title:Clinical Genetics
language:en
Short-container-title:Clinical Genetics

Author:

Finch Amy¹,Metcalfe Kelly¹²,Akbari Mohammad³^ORCID,Friedman Eitan⁴⁵,Tung Nadine⁶,Rosen Barry⁷,Eisen Andrea⁸,Karlan Beth⁹,Foulkes William¹⁰^ORCID,Neuhausen Susan L.¹¹,Senter Leigha¹²,McKinnon Wendy¹³,Elser Christine¹⁴,Sun Ping¹,Narod Steven A.¹³^ORCID,

Affiliation:

1. Women's College Research Institute Women's College Hospital Toronto Ontario Canada

2. Lawrence S. Bloomberg Faculty of Nursing University of Toronto Toronto Ontario Canada

3. Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada

4. The Meiray Center High Risk Clinic Chaim Sheba Medical Center Ramat Gan Israel

5. Sackler Faculty of Medicine Tel Aviv University Ramat Aviv Israel

6. Beth Israel Deaconess Medical Center Boston Massachusetts USA

7. Beaumont Health Royal Oak Michigan USA

8. Toronto‐Sunnybrook Regional Cancer Center Toronto Ontario Canada

9. Cedars‐Sinai Medical Center Los Angeles California USA

10. Program in Cancer Genetics, Department of Oncology and Human Genetics McGill University Montréal Canada

11. Department of Population Sciences Beckman Research Institute of City of Hope Duarte California USA

12. Division of Human Genetics The Ohio State University Medical Center, Comprehensive Cancer Center Columbus Ohio USA

13. Familial Cancer Program University of Vermont Medical Center Burlington Vermont USA

14. Marvelle Koffler Breast Centre Mount Sinai Hospital Toronto Ontario Canada

Funder

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cge.14098

Reference16 articles.

1. A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families

2. Incidence of non-founder BRCA1 and BRCA2 mutations in high risk Ashkenazi breast and ovarian cancer families

3. The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%

4. Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2

5. A comparison of the detection of BRCA mutation carriers through the provision of Jewish population-based genetic testing compared with clinic-based genetic testing