The efficacy of a transdermal hydrogel patch containing betamethasone dipropionate for treatment of chronic hand eczema: A single‐blind, randomized and controlled trial

Author:

Thaitirarot Sirinan1,Shuwisitkul Duangratana2,Udompataikul Montree1,Kamanamool Nanticha3,Kanokrungsee Silada1ORCID

Affiliation:

1. Department of Dermatology, Faculty of Medicine Srinakharinwirot University Bangkok Thailand

2. Faculty of Pharmacy Srinakharinwirot University Ongkharak Thailand

3. Department of Preventive and Social Medicine Srinakharinwirot University Bangkok Thailand

Abstract

AbstractBackgroundTopical corticosteroids under occlusion have been used to enhance the treatment of eczema. However, no study has investigated the efficacy of a steroid‐containing transdermal patch for the treatment of chronic hand eczema.MethodsWe conducted a randomized, controlled, assessor‐blinded trial to determine the efficacy of a transdermal patch containing betamethasone dipropionate compared to topical betamethasone dipropionate ointment in the treatment of mild to moderate chronic hand eczema. The patients were included and assigned to receive either the transdermal patch once daily at night or the ointment twice daily for a period of 8 weeks. The outcomes were assessed using the Hand Eczema Severity Index (HECSI), Physical Global Assessment (PGA) score, self‐reported compliance, level of patient satisfaction, quality of life, and side effects.ResultsFifty‐six patients completed this study. At 8 weeks, there was a significant reduction in the HECSI scores in both the transdermal patch and topical ointment groups compared to those measured at baseline (14.61 to 1.86, p < 0.001; 18.46 to 3.43, p < 0.001, respectively) without a statistically significant difference between the two groups. Similarly, the two groups did not show any significant difference in the PGA scores, quality of life and side effects. However, the transdermal patch group reported better compliance and a higher level of patient satisfaction than the topical ointment group.ConclusionThe transdermal corticosteroid patch has proven to be a safe and effective treatment, comparable to topical corticosteroids, after 8 weeks of use. Its sustained‐release properties, along with once‐daily use, can improve patient satisfaction and promote greater adherence to the treatment.Trial RegistrationThis study was registered with the Thai Clinical Trials Registry (www.clinicaltrials.in.th) under registration number TCTR20220413003.

Publisher

Wiley

Subject

Dermatology,Immunology and Allergy

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