Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group

Author:

Lavin Paola1ORCID,Rej Soham1ORCID,Olagunju Andrew T.2ORCID,Teixeira Antonio L.3,Dols Annemieke45ORCID,Alda Martin6ORCID,Almeida Osvaldo P.7ORCID,Altinbas Kursat8,Balanzá‐Martínez Vicent9,Barbosa Izabela G.10,Blumberg Hilary P.11ORCID,Briggs Farren12,Calkin Cynthia6ORCID,Cassidy Kristin12,Forester Brent P.13,Forlenza Orestes V.14,Hajek Tomas615ORCID,Haarman Barthomeus C. M.16ORCID,Jimenez Esther17,Lafer Beny18ORCID,Mulsant Benoit19,Oluwaniyi Stephen O.20,Patrick Regan21,Radua Joaquim172223,Schouws Sigfried45ORCID,Sekhon Harmehr113,Simhandl Christian24ORCID,Soares Jair C.925,Tsai Shang‐Ying26ORCID,Vieta Eduard17ORCID,Villa Luca M.1127ORCID,Sajatovic Martha28ORCID,Eyler Lisa T.2930ORCID

Affiliation:

1. Department of Geriatric Psychiatry, Department of Psychiatry Jewish General Hospital/Lady Davis Institute, McGill University Montreal Quebec Canada

2. Department of Psychiatry and Behavioral Neurosciences McMaster University/St Joseph's Healthcare Hamilton Hamilton Ontario Canada

3. Department of Psychiatry and Behavioral Sciences University of Texas/McGovern Medical School Houston Texas USA

4. Department of Old Age Psychiatry GGZ inGeest Amsterdam The Netherlands

5. Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam Neuroscience Amsterdam The Netherlands

6. Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada

7. Medical School University of Western Australia Perth Western Australia Australia

8. Selçuk University Medical Faculty, Department of Psychiatry Mazhar Osman Mood Clinic Konya Turkey

9. Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine University of Valencia, CIBERSAM Valencia Spain

10. Laboratório Interdisciplinar de Investigação Médica da Faculdad de Medicina Universidad Federal de Minas Gerais Belo Horizonte Brazil

11. Department of Psychiatry Yale School of Medicine New Haven Connecticut USA

12. Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA

13. Division of Geriatric Psychiatry McLean Hospital, Harvard Medical School Boston Massachusetts USA

14. Laboratory of Neuroscience (LIM‐27), Department and Institute of Psychiatry HCFMUSP, Faculdad de Medicina da Universidad de São Paulo São Paulo Brazil

15. National Institute of Mental Health Klecany Czech Republic

16. Department of Psychiatry University Medical Center Groningen, University of Groningen Groningen The Netherlands

17. Bipolar and Depressive Disorders Unit Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM Barcelona Catalonia Spain

18. Department of Psychiatry University of Sao Paulo São Paulo Brazil

19. Department of Psychiatry University of Toronto, Center for Addiction and Mental Health Toronto Ontario Canada

20. Federal Neuro‐psychiatric Hospital Yaba Lagos Nigeria

21. Division of Geriatric Psychiatry McLean Hospital Belmont Massachusetts USA

22. Department of Clinical Neuroscience, Centre for Psychiatric Research and Education Karolinska Institutet Solna Sweden

23. Institute of Psychiatry, Psychology, and Neuroscience King's College London London UK

24. Medical Faculty, Bipolar Center Wiener Neustadt Sigmund Freud University Wien Austria

25. Faillace Department of Psychiatry and Behavioral Sciences McGovern Medical School, UTHealth Houston Texas USA

26. Department of Psychiatry, School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan

27. Department of Psychiatry University of Oxford Oxford UK

28. Departments of Psychiatry and of Neurology Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center Cleveland Ohio USA

29. Department of Psychiatry University of California San Diego San Diego California USA

30. Desert‐Pacific Mental Illness Research Education and Clinical Center VA San Diego Healthcare System San Diego California USA

Abstract

AbstractBackgroundBy 2030, over 50% of individuals living with bipolar disorder (BD) are expected to be aged ≥50 years. However, older age bipolar disorder (OABD) remains understudied. There are limited large‐scale prospectively collected data organized in key dimensions capable of addressing several fundamental questions about BD affecting this subgroup of patients.MethodsWe developed initial recommendations for the essential dimensions for OABD data collection, based on (1) a systematic review of measures used in OABD studies, (2) a Delphi consensus of international OABD experts, (3) experience with harmonizing OABD data in the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE‐BD, n ≥ 4500 participants), and (4) critical feedback from 34 global experts in geriatric mental health.ResultsWe identified 15 key dimensions and variables within each that are relevant for the investigation of OABD: (1) demographics, (2) core symptoms of depression and (3) mania, (4) cognition screening and subjective cognitive function, (5) elements for BD diagnosis, (6) descriptors of course of illness, (7) treatment, (8) suicidality, (9) current medication, (10) psychiatric comorbidity, (11) psychotic symptoms, (12) general medical comorbidities, (13) functioning, (14) family history, and (15) other. We also recommend particular instruments for capturing some of the dimensions and variables.ConclusionThe essential data dimensions we present should be of use to guide future international data collection in OABD and clinical practice. In the longer term, we aim to establish a prospective consortium using this core set of dimensions and associated variables to answer research questions relevant to OABD.

Funder

International Society for Bipolar Disorders

Publisher

Wiley

Subject

Biological Psychiatry,Psychiatry and Mental health

Reference41 articles.

1. United Nations Department of Economic and Social Affairs Population Division(2015).World Population Ageing 2015 (ST/ESA/SER.A/390).http://www.un.org/esa/population/publications/worldageing19502050/pdf/80chapterii.pdfAccessed 11/12/2022

2. Epidemiology and risk factors for bipolar disorder

3. Bipolar disorder in older adults: a critical review

4. Predictors of psychiatric re-hospitalization in older adults with severe mental illness

5. The clinical course of late-life bipolar disorder, looking back and forward

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