<scp>PD‐L1</scp> expression downregulation by <scp>RNF43</scp> in gastric carcinoma enhances antitumour activity of T cells-Reference-Cited by-同舟云学术

PD‐L1 expression downregulation by RNF43 in gastric carcinoma enhances antitumour activity of T cells

Published:2023-04-13 Issue:6 Volume:97 Page:
ISSN:0300-9475
Container-title:Scandinavian Journal of Immunology
language:en
Short-container-title:Scand J Immunol

Author:

Yang Jing¹,Wei Meng²³,Liu Xin⁴,Shao Xiao⁵,Yan Jingshuang¹,Liu Jialong⁶,Wen Jing⁷,Zhang Xueting¹,Dong Ruihua⁸,Min Min¹^ORCID

Affiliation:

1. Department of Gastroenterology the First Medical Center of Chinese PLA General Hospital Beijing China

2. Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Nanning China

3. Key Laboratory of High‐Incidence‐Tumor Prevention and Treatment (Guangxi Medical University) Ministry of Education Nanning China

4. Department of Laboratory Medicine the Eighth Medical Center of Chinese PLA General Hospital Beijing China

5. Department of Pharmacology the Fifth Medical Center of Chinese PLA General Hospital Beijing China

6. Beijing Institute of Biotechnology Academy of Military Medical Sciences (AMMS) Beijing China

7. Department of Gastroenterology Chinese PLA 984 Hospital Beijing China

8. Department of Research Ward Beijing Friendship Hospital, Capital Medical University Beijing China

Abstract

AbstractRing finger protein 43 (RNF43), a transmembrane E3 ubiquitin ligase, has been indicated to be a potential biomarker for gastric cancer treatment, as this protein increases tumour cell apoptosis and suppresses cellular proliferation. The role of RNF43 in cellular immunotherapy remains unclear. Herein, we aimed to explore the expression level of RNF43 in gastric cancer cell lines and its role in cellular immunotherapy. The expression level of RNF43 and PD‐L1 and their correlation in gastric cancer cell lines were analysed. The expression of PD‐L1 was negatively correlated with that of RNF43 in gastric cancer cell lines. RNF43 interacted with PD‐L1 to augment both K48‐ and K63‐linked ubiquitination of PD‐L1 in gastric cancer cell lines. In addition, RNF43 expression in gastric cancer cell lines could enhance the antitumour activity of T cells. In conclusion, this study reveals that RNF43 can inhibit PD‐L1 expression to enhance the antitumour activity of cellular immunotherapy.

Publisher

Wiley

Subject

Immunology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/sji.13268

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