Affiliation:
1. Pathology Unit, Department of Medical Sciences University of Turin Turin Italy
2. Pathology Unit Città della Salute e della Scienza University Hospital Turin Italy
Abstract
AimsThe current criteria for surgical treatment after endoscopic resection of a pT1 colorectal carcinoma (CRC) are unsatisfactory because nodal involvement is rarely present. This study investigates the correlation between PD‐L1 expression and nodal metastasis in pT1 CRCs to enable its use for tailoring surgical treatment after endoscopic removal.Methods and resultsHistopathological features of 81 surgically resected pT1 CRC, 19 metastatic and 62 non‐metastatic cases were assessed. PD‐L1 expression was evaluated by immunohistochemistry (clone 22C3) and independently assessed by two pathologists using tumour proportion score (TPS), combined positive score (CPS) and immune cell score (ICS). The correlation between PD‐L1 expression and nodal metastasis, the optimal cut‐off values, interobserver agreement and impact upon patients' surgical management were determined. PD‐L1 expression in terms of CPS and ICS independently correlated with lymph node metastasis (PD‐L1CPS: OR = –2.5, 95% CI = −4.11 to −0.97, P = 0.008 and PD‐L1ICS: OR = −1.85, 95% CI = −2.90 to −0.79, P = 0.004) and < 1.2 CPS and <1.3% ICS were identified as the optimal cut‐off values to discriminate between metastatic and non‐metastatic patients. In our cohort, the implementation of these cut‐off values would have avoided a significant rate of unnecessary surgeries in pN0 patients (PD‐L1CPS = 43.2; PD‐L1ICS = 51.9%). Ultimately, PD‐L1 evaluation showed good interpathologist concordance in absolute terms [PD‐L1CPS interclass correlation coefficient (ICC) = 0.91; PD‐L1ICS ICC = 0.793] and using the identified cut‐off values (PD‐L1CPS ICC = 0.848; PD‐L1ICS ICC = 0.756).ConclusionsOur study shows that PD‐L1 expression is an effective predictor of nodal status and could improve patient selection for surgery after endoscopic removal of pT1 CRCs.
Funder
Rete Oncologica del Piemonte e della Valle d'Aosta
Subject
General Medicine,Histology,Pathology and Forensic Medicine
Cited by
2 articles.
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