Affiliation:
1. Department of Microbiology and Parasitology Consorcio Hospital General Universitario de Valencia Valencia Spain
2. Department of Microbiology and Ecology University of Valencia Valencia Spain
Abstract
AbstractBackgroundCandida auris has become a worrisome multi‐drug resistant healthcare‐associated pathogen due to its capacity to colonise patients and surfaces and to cause outbreaks of invasive infections in critically ill patients.ObjectivesThis study evaluated the outbreak in our setting in a 4‐year period, reporting the risk factors for developing candidemia in previously colonised patients, the therapeutic measures for candidemia and the outcome of candidemia and colonisation cases among all C. auris isolates and their susceptibility to antifungals.MethodsData were retrospectively collected from patients admitted to Consorcio Hospital General Universitario de Valencia (Spain) from September 2017 to September 2021. A retrospective case–control study was designed to identify risk factors for developing C. auris candidemia in previously colonised patients.ResultsC. auris affected 550 patients, of which 210 (38.2%) had some clinical sample positive. Isolates were uniformly resistant to fluconazole, 20 isolates were resistant to echinocandins (2.8%) and four isolates were resistant to ampfotericin B (0.6%). There were 86 candidemia cases. APACHE II, digestive disease and catheter isolate were proven to be independent risk factors for developing candidemia in previously colonised patients. Thirty‐day mortality rate for C. auris candidemia cases was 32.6%, while for colonisation cases was 33.7%.ConclusionsCandidemia was one of the most frequent and severe infections caused by C. auris. The risk factors identified in this study should help to detect patients who are at more risk of developing candidemia, as long as an adequate surveillance of C. auris colonisation is performed.
Subject
Infectious Diseases,Dermatology,General Medicine