Occupational interstitial lung diseases

Author:

Spagnolo Paolo1ORCID,Ryerson Christopher J.2,Guler Sabina3,Feary Johanna45,Churg Andrew6,Fontenot Andrew P.78,Piciucchi Sara9,Udwadia Zarir10,Corte Tamera J.1112,Wuyts Wim A.13,Johannson Kerri A.1415,Cottin Vincent1617

Affiliation:

1. Respiratory Disease Unit Department of Cardiac, Thoracic Vascular Sciences and Public Health University of Padova Padova Italy

2. Department of Medicine St. Paul's Hospital University of British Columbia and Centre for Heart Lung Innovation Vancouver Canada

3. Department of Pulmonary Medicine Inselspital Bern University Hospital University of Bern Bern Switzerland

4. Department of Occupational and Environmental Medicine Royal Brompton Hospital London UK

5. National Heart and Lung Institute Imperial College London London UK

6. Department of Pathology University of British Columbia Vancouver British Columbia Canada

7. Department of Medicine University of Colorado Anschutz Medical Campus Aurora Aurora Colorado USA

8. Department of Immunology and Microbiology University of Colorado Anschutz Medical Campus Aurora Aurora Colorado USA

9. Department of Radiology G.B. Morgagni Hospital/University of Bologna Forlì Italy

10. Hinduja Hospital and Research Center Breach Candy Hospital Mumbai Maharashtra India

11. NHMRC Centre of Research Excellence in Pulmonary Fibrosis Camperdown New South Wales Australia

12. Department of Respiratory Medicine Royal Prince Alfred Hospital Sydney New South Wales Australia

13. Unit for Interstitial Lung Diseases University of Leuven Leuven Belgium

14. Department of Medicine University of Calgary Calgary Alberta Canada

15. Department of Community Health Sciences University of Calgary Calgary Alberta Canada

16. Department of Respiratory Medicine National Reference Coordinating Centre for Rare Pulmonary Diseases Louis Pradel Hospital Hospices Civils de Lyon Lyon France

17. Université de Lyon Université Claude Bernard Lyon 1, UMR754, IVPC Lyon France

Abstract

AbstractMillions of workers are exposed to substances known to cause occupational interstitial lung diseases (ILDs), particularly in developing countries. However, the burden of the disease is likely to be underestimated due to under‐recognition, under‐reporting or both. The diagnosis of occupational ILD requires a high level of suspicion and a thorough occupational history, as occupational and non‐occupational ILDs may be clinically, functionally and radiologically indistinguishable, leading to delayed diagnosis and inappropriate management. A potential occupational aetiology should always be considered in the differential diagnosis of ILD, as removal from the workplace exposure, with or without treatment, is a key therapeutic intervention and may lead to significant improvement. In this article, we provide an overview of the ‘traditional’ inorganic dust‐related ILDs but also address idiopathic pulmonary fibrosis and the immunologically mediated chronic beryllium disease, sarcoidosis and hypersensitivity pneumonitis, with emphasis on the importance of surveillance and prevention for reducing the burden of these conditions. To this end, health‐care professionals should be specifically trained about the importance of occupational exposures as a potential cause of ILD.

Publisher

Wiley

Subject

Internal Medicine

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