Gestational diabetes mellitus is associated with greater incidence of dementia during long‐term post‐partum follow‐up

Author:

Zhang Yang1ORCID,Gao Darui23ORCID,Gao Ying1,Li Jing4,Li Chenglong23,Pan Yang4,Wang Yongqian23ORCID,Zhang Junqing1,Zheng Fanfan4ORCID,Xie Wuxiang23

Affiliation:

1. Department of Endocrinology Peking University First Hospital Beijing China

2. Heart and Vascular Health Research Center Peking University Clinical Research Institute Peking University First Hospital Beijing China

3. Key Laboratory of Epidemiology of Major Diseases (Peking University) Ministry of Education Beijing China

4. School of Nursing Peking Union Medical College Chinese Academy of Medical Sciences Beijing China

Abstract

AbstractBackgroundThe impact of gestational diabetes mellitus (GDM) on incident dementia is unknown. Our aim was to evaluate the relationship between GDM and all‐cause dementia and the mediating effects of chronic diseases on this relationship.MethodsThis prospective cohort study included women from the UK Biobank who were grouped based on GDM history. Multivariate Cox proportional hazard models were used to explore the associations between GDM and dementia. We further analysed the mediating effects of chronic diseases on this relationship and the interactions of covariates.ResultsA total of 1292 women with and 204,171 women without a history of GDM were included. During a median follow‐up period of 45 years after first birth, 2921 women were diagnosed with dementia. Women with a GDM history had a 67% increased risk of incident dementia (hazard ratio 1.67, 95% confidence interval: 1.03–2.69) compared with those without a GDM history. According to mediation analyses, type 2 diabetes, coronary heart disease, chronic kidney disease and comorbidities (diagnosed with any two of the three diseases) explained 34.5%, 8.4%, 5.2% and 18.8% of the mediating effect on the relationship. Subgroup analyses revealed that physical activity modified the association between GDM history and dementia (p for interaction = 0.030). Among physically inactive women, GDM was significantly associated with incident dementia; however, this association was not observed among physically active women.ConclusionsA history of GDM was associated with a greater risk of incident dementia. Type 2 diabetes partially mediated this relationship. Strategies for dementia prevention might be considered for women with a history of GDM.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3