Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study

Author:

Kalman Janos L123,Papiol Sergi124,Forstner Andreas J567,Heilbronner Urs18,Degenhardt Franziska5,Strohmaier Jana9,Adli Mazda10,Adorjan Kristina12,Akula Nirmala11,Alda Martin12,Anderson-Schmidt Heike18,Andlauer Till FM13,Anghelescu Ion-George14,Ardau Raffaella15,Arias Bárbara16,Arolt Volker17,Aubry Jean-Michel18,Backlund Lena19,Bartholdi Kim1,Bauer Michael20,Baune Bernhard T21,Becker Thomas22,Bellivier Frank23,Benabarre Antonio24,Bengesser Susanne25,Bhattacharjee Abesh Kumar26,Biernacka Joanna M27,Birner Armin25,Brichant-Petitjean Clara23,Budde Monika1,Cervantes Pablo28,Chillotti Caterina15,Cichon Sven57,Clark Scott R21,Colom Francesc29,Comes Ashley L13,Cruceanu Cristiana1328,Czerski Piotr M30,Dannlowski Udo17,Dayer Alexandre18,Del Zompo Maria31,DePaulo Jay Raymond32,Dietrich Detlef E33,Étain Bruno23,Ethofer Thomas34,Falkai Peter2,Fallgatter Andreas34,Figge Christian35,Flatau Laura1,Folkerts Here36,Frisen Louise19,Frye Mark A27,Fullerton Janice M3738,Gade Katrin18,Gard Sébastien39,Garnham Julie S12,Goes Fernando S32,Grigoroiu-Serbanescu Maria40,Gryaznova Anna1,Hake Maria1,Hauser Joanna30,Herms Stefan57,Hoffmann Per57,Hou Liping11,Jäger Markus22,Jamain Stephane41,Jiménez Esther24,Juckel Georg42,Kahn Jean-Pierre43,Kassem Layla44,Kelsoe John26,Kittel-Schneider Sarah45,Kliwicki Sebastian46,Klohn-Sagatholislam Farah12,Koller Manfred47,König Barbara48,Konrad Carsten49,Lackner Nina25,Laje Gonzalo11,Landén Mikael5051,Lang Fabian U22,Lavebratt Catharina39,Leboyer Marion4152,Leckband Susan G53,Maj Mario54,Manchia Mirko5556,Martinsson Lina57,McCarthy Michael J26,McElroy Susan L58,McMahon Francis J11,Mitchell Philip B5960,Mitjans Marina61,Mondimore Francis M32,Monteleone Palmiero5462,Nieratschker Vanessa34,Nievergelt Caroline M26,Novák Tomas6364,Ösby Urban65,Pfennig Andrea20,Potash James B66,Reich-Erkelenz Daniela1,Reif Andreas45,Reimer Jens67,Reininghaus Eva25,Reitt Markus8,Ripke Stephan1068,Rouleau Guy A28,Rybakowski Janusz K46,Schalling Martin19,Scherk Harald69,Schmauß Max70,Schofield Peter R3738,Schubert K Oliver21,Schulte Eva C12,Schulz Sybille67,Senner Fanny12,Severino Giovanni31,Shekhtman Tatyana26,Shilling Paul D26,Simhandl Christian7172,Slaney Claire M12,Spitzer Carsten73,Squassina Alessio31,Stamm Thomas1074,Stegmaier Sophia34,Stierl Sebastian75,Stopkova Pavla63,Thiel Andreas49,Tighe Sarah K66,Tortorella Alfonso76,Turecki Gustavo77,Vieta Eduard24,Veeh Julia45,von Hagen Martin78,Wigand Moritz E22,Wiltfang Jens8,Witt Stephanie9,Wright Adam5960,Zandi Peter P32,Zimmermann Jörg67,Nöthen Markus5,Rietschel Marcella9,Schulze Thomas G1

Affiliation:

1. Institute of Psychiatric Phenomics and Genomics (IPPG); University Hospital; LMU Munich; Munich Germany

2. Department of Psychiatry and Psychotherapy; Ludwig-Maximilians-University Munich; Munich Germany

3. International Max Planck Research School for Translational Psychiatry (IMPRS-TP); Munich Germany

4. Instituto de Salud Carlos III; Biomedical Network Research Centre on Mental Health (CIBERSAM); Barcelona Spain

5. Institute of Human Genetics; University of Bonn and Department of Genomics; Life & Brain Center; Bonn Germany

6. Department of Psychiatry (UPK); University of Basel; Basel Switzerland

7. Human Genomics Research Group; Department of Biomedicine; University of Basel; Basel Switzerland

8. Department of Psychiatry and Psychotherapy; University Medical Center (UMG); Georg-August University Göttingen; Göttingen Germany

9. Department of Genetic Epidemiology in Psychiatry; Central Institute of Mental Health; Medical Faculty Mannheim; University of Heidelberg; Mannheim Germany

10. Department of Psychiatry and Psychotherapy; Charité - Universitätsmedizin Berlin; Berlin Germany

11. Intramural Research Program; National Institute of Mental Health; National Institutes of Health; US Dept of Health & Human Services; Bethesda MD USA

12. Department of Psychiatry; Dalhousie University; Halifax NS Canada

13. Max Planck Institute of Psychiatry; Munich Germany

14. Private Neuropathic Hospital Dr. med. Kurt Fontheim; Liebenburg Germany

15. Unit of Clinical Pharmacology; Hospital University Agency of Cagliari; Cagliari Italy

16. Departament Biologia Evolutiva; Ecologia i Ciències Ambientals; Facultat de Biologia; Institut de Biomedicina de la Universitat de Barcelona (IBUB); CIBERSAM; Universitat de Barcelona; Barcelona Spain

17. Department of Psychiatry; University of Münster; Münster Germany

18. Mood Disorders Unit; Department of Psychiatry; HUG - Geneva University Hospitals; Geneva Switzerland

19. Department of Molecular Medicine and Surgery; Karolinska Institutet and The Centre for Psychiatric Research; Stockholm Sweden

20. Department of Psychiatry and Psychotherapy; Carl Gustav Carus University Hospital; Technische Universität Dresden; Dresden Germany

21. Discipline of Psychiatry; Royal Adelaide Hospital; Adelaide School of Medical Schooline; The University of Adelaide; Adelaide SA Australia

22. Department of Psychiatry II; Ulm University; Bezirkskrankenhaus Günzburg; Günzburg Germany

23. INSERM UMR-S 1144 - Université Paris Diderot; Pôle de Psychiatrie; AP-HP, Groupe Hospitalier Lariboisière-F. Widal; Paris France

24. Bipolar Disorders Program; Institute of Neurosciences; Hospital Clinic; University of Barcelona; IDIBAPS, CIBERSAM; Barcelona Spain

25. Medical University of Graz; Graz Austria

26. Department of Psychiatry; University of California San Diego; San Diego CA USA

27. Mayo Clinic; Rochester MN USA

28. Mood Disorders Program; McGill University Health Centre; Montreal QC Canada

29. Mental Health Program; IMIM (Hospital del Mar Medical Research Institute); CIBERSAM Barcelona; Catolonia Spain

30. Laboratory of Psychiatric Genetics; Poznan University of Medical Sciences; Poznan Poland

31. Department of Biomedical Sciences; University of Cagliari; Cagliari Italy

32. Department of Psychiatry and Behavioral Sciences; Johns Hopkins University; Baltimore MD USA

33. AMEOS Clinical Center Hildesheim; Hildesheim Germany

34. Department of Psychiatry and Psychotherapy; Neurophysiology & Interventional Neuropsychiatry; University of Tübingen; Tübingen Germany

35. Karl-Jaspers Clinic; European Medical School Oldenburg-Groningen; Oldenburg Germany

36. Department of Psychiatry, Psychotherapy and Psychosomatics; Clinical Center Wilhelmshaven; Wilhelmshaven Germany

37. Neuroscience Research Australia; Sydney NSW Australia

38. School of Medical Sciences; University of New South Wales; Sydney NSW Australia

39. CH Ch Perrens; Bordeaux France

40. Biometric Psychiatric Genetics Research Unit; Alexandru Obregia Clinical Psychiatric Hospital; Bucharest Romania

41. INSERM U955 Equipe 15 - Psychiatrie Genetique; Hopital Henri Mondor; Creteil Cedex France

42. Department of Psychiatry; Ruhr University Bochum; LWL University Hospital; Bochum Germany

43. Service de Psychiatrie et Psychologie Clinique; Centre Psychothérapique de Nancy - Université de Lorraine; Nancy France

44. Human Genetics Branch; Section on Genetic Basis of Mood and Anxiety Disorders; National Institutes of Health; Bethesda MD USA

45. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy; University Hospital Frankfurt; Frankfurt Germany

46. Department of Adult Psychiatry; Poznan University of Medical Sciences; Poznan Poland

47. Asklepios Specialized Hospital; Göttingen Germany

48. Hospital Neunkirchen; Neunkirchen Germany

49. Department of Psychiatry and Psychotherapy; Agaplesion Diakonieklinikum; Rotenburg Germany

50. Gothenburg University; Sahlgrenska Academy; Gothenburg Sweden

51. Department of Medical Epidemiology and Biostatistics; Karolinska Institutet; Stockholm Sweden

52. Assistance Publique-Hôpitaux de Paris; Hôpital Albert Chenevier - Henri Mondor; Pôle de Psychiatrie; Créteil France

53. Department of Pharmacy; VA San Diego Healthcare System; San Diego CA USA

54. Department of Psychiatry; Campania University L. Vanvitelli; Naples Italy

55. Section of Psychiatry; Department of Public Health, Clinical and Molecular Medicine; University of Cagliari; Cagliari Italy

56. Department of Pharmacology; Dalhousie University; Halifax NS Canada

57. Department of Clinical Neurosciences; Karolinska Institutet; Stockholm Sweden

58. Lindner Center of HOPE; Research Institute; Mason OH USA

59. School of Psychiatry; University of New South Wales; Sydney NSW Australia

60. Black Dog Institute; Prince of Wales Hospital; Sydney NSW Australia

61. Unitat d'Antropologia (Dp. Biología Animal); Department of Biologia Animal; Facultat de Biologia and Institut de Biomedicina (IBUB); Universitat de Barcelona; CIBERSAM; Barcelona Spain

62. Neurosciences Section; Department of Medicine and Surgery; University of Salerno; Salerno Italy

63. National Institute of Mental Health; Klecany Czech Republic

64. Third Faculty of Medicine; Charles University in Prague; Prague Czech Republic

65. Department of Psychiatry; Karolinska Institutet; Stockholm Sweden

66. Psychiatry; University of Iowa; Iowa City IA USA

67. Department of Psychiatry; Klinikum Bremen-Ost; Bremen Germany

68. Stanley Center for Psychiatric Research; Broad Institute; Cambridge MA USA

69. AMEOS Clinical Center Osnabrück; Osnabrück Germany

70. Department of Psychiatry and Psychotherapy; Bezirkskrankenhaus Augsburg; Augsburg Germany

71. Sigmund Freud University; Vienna Austria

72. Bipolar Zentrum; Wiener Neustadt Austria

73. ASKLEPIOS Specialized Hospital Tiefenbrunn; Rosdorf Germany

74. Department of Psychiatry, Psychotherapy and Psychosomatics; Medical School Brandenburg; Neuruppin Germany

75. Psychiatric Hospital Lüneburg; Lüneburg Germany

76. Department of Psychiatry; University of Perugia; Perugia Italy

77. Douglas Hospital; Verdun QC Canada

78. Clinic for Psychiatry and Psychotherapy; Clinical Center Werra-Meißner; Eschwege Germany

Funder

Vetenskapsrådet

Stockholms Läns Landsting

Karolinska Institutet

Söderström-Königska Foundation

Deutsche Forschungsgemeinschaft

Dr. Lisa Oehler Foundation

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii

Bundesministerium für Bildung und Forschung

Alfried Krupp von Bohlen und Halbach-Stiftung

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

LMU Mentoring Program of Ludwig-Maximilians Universität

Brain and Behavior Research Foundation

Publisher

Wiley

Subject

Biological Psychiatry,Psychiatry and Mental health

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