Affiliation:
1. Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
2. Clinical Biostatistics Department Biomedical Informatics Consultants LLC Potomac Maryland USA
3. Global Medical and Clinical Affairs, Medtronic Diabetes Northridge California USA
Abstract
AbstractAimTo investigate the association between a new composite metric, glycaemia risk index (GRI), and incident diabetic retinopathy (DR).MethodsA total of 1204 adults with type 2 diabetes without DR at baseline were included between 2005 and 2019 from a single centre in Shanghai, China. GRI was obtained from continuous glucose monitoring data at baseline. Cox proportion hazard regression analysis was used to assess the association between GRI and the risk of incident DR.ResultsDuring a median follow‐up of 8.4 years, 301 patients developed DR. The multivariable‐adjusted hazard ratios (HRs) for incident DR across ascending GRI quartiles (≤14 [reference], 15 ~ 28, 29 ~ 47 and > 47) were 1.00, 1.05 (95% CI 0.74‐1.48), 1.33 (95% confidence interval [CI] 0.96‐1.84) and 1.53 (95% CI 1.11‐2.11), respectively. For each 1‐SD increase in GRI, the risk of DR was increased by 20% (HR 1.20, 95% CI 1.07‐1.33) after adjustment for confounders.ConclusionsIn patients with type 2 diabetes, higher GRI is associated with an increased risk of incident DR. GRI has the potential to be a valuable clinical measure, which needs to be further explored in future studies.
Funder
Program of Shanghai Academic Research Leader
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
6 articles.
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