Dose response signal detection under model uncertainty

Author:

Dette Holger1,Titoff Stefanie2,Volgushev Stanislav1,Bretz Frank3

Affiliation:

1. Ruhr-Universität Bochum; Fakultät für Mathematik; 44780 Bochum Germany

2. Continentale Krankenversicherung a.G. Ruhrallee 92; 44139 Dortmund Germany

3. Novartis Pharma AG, Lichtstrasse 35, 4002 Basel; Switzerland and Shanghai University of Finance and Economics; People's Republic of China

Publisher

Wiley

Subject

Applied Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,Statistics and Probability

Reference48 articles.

1. The impact of dropouts on the analysis of dose-finding studies with recurrent event data;Akacha;Statistics in Medicine,2010

2. Optimal tests when a nuisance parameter is present only under the alternative;Andrews;Econometrica,1994

3. Admissibility of the likelihood ratio test when a nuisance parameter is present only under the alternative;Andrews;Annals of Statistics,1995

4. Model-based approaches for time-dependent dose finding with repeated binary data;Benda;Statistics in Medicine,2010

5. Many-to-one comparisons in stratified designs;Biesheuvel;Biometrical Journal,2002

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