Optimal treatment strategy and prognostic analysis of salvage liver transplantation for patients with early hepatocellular carcinoma recurrence after hepatectomy

Abstract

AbstractAimWe aimed to investigate the prognostic factors for salvage liver transplant in patients with early hepatocellular carcinoma recurrence after hepatectomy.MethodsThis retrospective analysis included 53 patients who underwent salvage living‐donor liver transplantation between January 2007 and January 2018. There were 24 and 29 patients in the early (recurrence ≤24 months after primary liver resection) and the late recurrence groups, respectively.ResultsIn the multivariate Cox regression model, pre‐liver transplant downstaging therapy, early recurrence (ER) after primary liver resection , and recurrence‐to‐liver‐transplant ≥12 months were independent risks to predict recurrent hepatocellular carcinoma recurrence after salvage living‐donor liver transplantation. Compared with the late recurrence group, the ER group showed lower disease‐free survival rates (p < 0.001); however, the overall survival rates did not differ between the two groups (p = 0.355). The 1‐, 3‐, and 5‐year disease‐free survival rates were 83.3%, 70.6%, and 66.2%, and 96.0%, 91.6%, and 91.6% in the early and late recurrence groups, respectively. When stratified by recurrence‐to‐liver transplant time and pre‐liver transplant downstaging therapy in the ER group, disease‐free survival and overall survival rates were significantly different.ConclusionER after primary liver resection with advanced tumor status and a longer period of recurrence‐to‐liver‐transplant (≥12 months) have a negative impact on salvage liver transplant. Our findings provide novel recommendations for treatment strategies and eligibility for salvage liver transplant candidates.