Affiliation:
1. Second Department of Internal Medicine Osaka Medical and Pharmaceutical University Takatsuki Osaka Japan
2. Osaka Medical and Pharmaceutical University Health Science Clinic Takatsuki Osaka Japan
3. Department of Gastroenterology Kobe Asahi Hospital Kobe Hyogo Japan
Abstract
AbstractAimTo examine the relationship between changes in alanine aminotransferase (ALT) and those in body composition and metabolic factors in participants receiving medical health checkups (4350 men [mean age 52.5 years] and 5398 women [mean age 50.5 years])MethodsWe divided the participants into four types based on their ALT value at baseline and 1 year: A, ALT ≤30 (baseline) and ≤30 (1 year); B, ALT ≥31 (baseline) and ≤30 (1 year); C, ALT ≤30 (baseline) and ≥31 (1 year); and D, ALT ≥31 (baseline) and ≥31 (1 year). The change in each body composition‐related parameter (waist circumference, fat mass, fat‐free mass, fat mass to fat‐free mass ratio, etc.) after 1‐year was defined as Δ.ResultsThe mean changes in waist circumference (cm) in the four types (A, B, C, and D) were −0.33, −1.54, 0.66, and −0.29 (overall p < 0.0001) in men, and −0.19, −0.90, 0.30, and 0.090 (overall p < 0.0001) in women. The mean changes in fat mass (kg) in the four types were −0.027, −0.86, 0.62, and 0.092 (overall p < 0.0001) in men, and 0.0067, −0.48, 0.39, and 0.063 (overall p < 0.0001) in women. The mean changes in fat‐free mass (kg) in the four types were −0.028, −0.55, 0.42, and −0.034 (overall p < 0.0001) in men, and −0.0091, −0.34, 0.12, and −0.045 (overall p = 0.0012) in women. The mean changes in fat mass to fat‐free mass ratio in the four types were −0.00042, −0.0120, 0.00837, and 0.00171 (overall p < 0.0001) in men, and −0.00013, −0.00817, 0.00730, and 0.00628 (overall p < 0.0001) in women.ConclusionA decrease in ALT to ≤30 IU/L may be associated with improved body composition balance, but caution should be exercised for the decrease in muscle mass.