Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4
Author:
Affiliation:
1. Department of Biochemistry University of Cambridge Cambridge UK
2. Neuroscience, BioPharmaceuticals R&D AstraZeneca Cambridge UK
Funder
Medical Research Council
AstraZeneca
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15024
Reference28 articles.
1. Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons
2. Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling
3. Lentiviral transduction of microglial cells
4. Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus
5. Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation
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