Treated periodontitis and recurrent events after first‐time myocardial infarction: A Danish nationwide cohort study

Author:

Wagner Andrea Kjellström1,D'Souza Maria1,Bang Casper N.2,Holmstrup Palle3,Blanche Paul4,Fiehn Nils‐Erik3,Gislason Gunnar156,Pedersen Christian Torp7,Damgaard Christian3ORCID,Nielsen Claus Henrik38,Hansen Peter Riis15

Affiliation:

1. Department of Cardiology Copenhagen University Hospital ‐ Herlev and Gentofte Hellerup Denmark

2. Department of Cardiology Copenhagen University Hospital ‐ Bispebjerg and Frederiksberg Copenhagen Denmark

3. Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

4. Section of Biostatistics University of Copenhagen Copenhagen Denmark

5. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

6. The Danish Heart Foundation Copenhagen Denmark

7. Department of Cardiology Copenhagen University Hospital ‐ North Zealand Hilleroed Denmark

8. Institute for Inflammation Research, Center for Rheumatology and Spine Diseases Copenhagen University Hospital ‐ Rigshospitalet Copenhagen Denmark

Abstract

AbstractAimTo investigate the association between previous periodontal treatment and recurrent events after first‐time myocardial infarction (MI).Materials and MethodsFrom the Danish nationwide registries, patients with first‐time MI between 2000 and 2015 were divided into three groups according to oral health care within 1 year prior to first‐time MI. A multiple logistic regression model provided adjusted odds ratios (ORs) with 95% confidence intervals (CIs) to assess the 3‐year risk of major adverse cardiovascular events (MACE).ResultsA total of 103,949 patients were included. Patients with treated periodontitis (PD) prior to first‐time MI had an adjusted 3‐year risk of MACE similar to patients presumed periodontally healthy (OR 0.97 [95% CI 0.92–1.03]). Patients with no prior dental visits were significantly older, had more comorbidities and showed significantly increased adjusted 3‐year risks of MACE (OR 1.47 [95% CI 1.42–1.52]), cardiovascular death (OR 1.71 [95% CI 1.64–1.78]) and heart failure (OR 1.13 [95% CI 1.07–1.20]) compared with patients presumed periodontally healthy.ConclusionsPatients with treated PD 1 year prior to first‐time MI had a similar risk of recurrent cardiovascular events as patients presumed periodontally healthy. No dental visit prior to first‐time MI was an independent risk factor for recurrent events.

Funder

Helsefonden

Novo Nordisk Fonden

Publisher

Wiley

Subject

Periodontics

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