<scp>XRCC1</scp>counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped<scp>PARP1</scp>from broken<scp>DNA</scp>-Reference-Cited by-同舟云学术

XRCC1counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trappedPARP1from brokenDNA

Published:2022-03 Issue:5 Volume:27 Page:331-344
ISSN:1356-9597
Container-title:Genes to Cells
language:en
Short-container-title:Genes to Cells

Author:

Hirota Kouji¹²^ORCID,Ooka Masato²³,Shimizu Naoto¹,Yamada Kousei¹,Tsuda Masataka¹⁴,Ibrahim Mahmoud Abdelghany¹,Yamada Shintaro¹,Sasanuma Hiroyuki¹,Masutani Mitsuko⁵,Takeda Shunichi⁶

Affiliation:

1. Department of Radiation Genetics Graduate School of Medicine, Kyoto University Kyoto Japan

2. Department of Chemistry, Graduate School of Science Tokyo Metropolitan University Tokyo Japan

3. Division of Pre‐Clinical Innovation National Center for Advancing Translational Sciences, National Institutes of Health Bethesda Maryland USA

4. Department of Mathematical and Life Sciences, Graduate School of Science Hiroshima University Hiroshima Japan

5. Department of Molecular and Genomic Biomedicine, CBMM Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan

6. Shenzhen University School of Medicine Shenzhen Guangdong China

Funder

Japan Society for the Promotion of Science

Takeda Pharmaceutical Company

Publisher

Wiley

Subject

Cell Biology,Genetics

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/gtc.12929

Reference73 articles.

1. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair

2. Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

3. Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK

4. Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

5. The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks

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