Phase 2a, randomized, double‐blind, placebo‐controlled, multicentre, parallel‐group study of an H 4 R‐antagonist ( JNJ ‐39758979) in adults with uncontrolled asthma-Reference-Cited by-同舟云学术

Phase 2a, randomized, double‐blind, placebo‐controlled, multicentre, parallel‐group study of an H 4 R‐antagonist ( JNJ ‐39758979) in adults with uncontrolled asthma

Published:2018-06-06 Issue:8 Volume:48 Page:957-969
ISSN:0954-7894
Container-title:Clinical & Experimental Allergy
language:en
Short-container-title:Clin Exp Allergy

Author:

Kollmeier A. P.¹^ORCID,Greenspan A.¹,Xu X. L.¹,Silkoff P. E.²,Barnathan E. S.²,Loza M. J.²,Jiang J.¹,Zhou B.²,Chen B.¹,Thurmond R. L.¹

Affiliation:

1. Janssen Research & Development, LLC San Diego CA USA

2. Janssen Research & Development, LLC Spring House PA USA

Funder

Janssen Research and Development

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cea.13154

Reference32 articles.

1. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness.

2. Eosinophils and Mast Cells in Bronchoalveolar Lavage in Subjects with Mild Asthma: Relationship to Bronchial Hyperreactivity

3. Activation of Pulmonary Mast Cells by Bronchoalveolar Allergen Challenge:In VivoRelease of Histamine and Tryptase in Atopic Subjects with and without Asthma

4. Evidence for Elevated Levels of Histamine, Prostaglandin D2, and Other Bronchoconstricting Prostaglandins in the Airways of Subjects with Mild Asthma

5. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway

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