Biosynthesis of 1α-hydroxycorticosterone in the winter skateLeucoraja ocellata: evidence to suggest a novel steroidogenic route

Author:

Wiens J.1,Ho R.2,Brassinga A. K.2,Deck C. A.3,Walsh P. J.3,Ben R. N.4,Mcclymont K.4,Charlton T.4,Evans A. N.5,Anderson W. G.1

Affiliation:

1. Department of Biological Sciences; University of Manitoba; Winnipeg MB R3T 2N2 Canada

2. Department of Microbiology; University of Manitoba; Winnipeg MB R3T 2N2 Canada

3. Department of Biology; University of Ottawa; Ottawa Ontario K1N 6N5 Canada

4. Department of Chemistry; University of Ottawa; Ottawa ON K1N 6N5 Canada

5. Department of Coastal Sciences, Gulf Coast Research Laboratory; University of Southern Mississippi, 703 East Beach Drive; Ocean Springs MS U.S.A.

Funder

NSERC Undergraduate Student Research Award

NSERC Discovery

Canada Research Chairs Program

Publisher

Wiley

Subject

Aquatic Science,Ecology, Evolution, Behavior and Systematics

Reference40 articles.

1. Microbiological 1α-hydroxylation of norethisterone;Ambrus;Steroids,1975

2. The endocrinology of 1α-hydroxycorticosterone in elasmobranch fish: a review;Anderson;Comparative Biochemistry and Physiology Part A, Molecular and Integrative Physiology,2012

3. Microbial production of 3-oxobisnorchola-1,4-dien-22-oic acid;Arima;Agricultural and Biological Chemistry,1978

4. Mechanisms of ACTH- and angiotensin II-stimulated 1α-hydroxycorticosterone secretion in the dogfish, Scyliorhinus canicula;Armour;Journal of Molecular Endocrinology,1993

5. Regio- and stereoselective epoxidation of steroidal 1,4-diene-3-ones by dimethyldioxirane: a new access to A-norsteroids and to a class of estrogen synthaseinhibitors;Bovicelli;Journal of Organic Chemistry,1994

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