Effect of interleukin‐12 gene expression on insulin resistance in patients with acne vulgaris

Author:

AbdElneam Ahmed Ibrahim12,Al‐Dhubaibi Mohammed Saleh3,Bahaj Saleh Salem4,Mohammed Ghada Farouk5,Alantry Ahmed Kaid6,Atef Lina M.5

Affiliation:

1. Department of Clinical Biochemistry, Department of Basic Medical Sciences, College of Medicine Shaqra University Dawadmi Saudi Arabia

2. Molecular Genetics and Enzymology Department, Human Genetics and Genome Research Institute National Research Center Dokki Cairo Egypt

3. Departments of Dermatology, College of Medicine Shaqra University Dawadmi Saudi Arabia

4. Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences Sana'a University Sanaʽa Yemen

5. Department of Dermatology, Venereology, and Sexology, Faculty of Medicine Suez Canal University Ismailia Egypt

6. Physiology Department, Unaizah College of Medicine Qassim University Unaizah Saudi Arabia

Abstract

AbstractBackgroundInsulin resistance (IR) is a condition where cells become resistant to insulin, causing impaired glucose uptake and increased blood glucose levels. Interleukin‐12 (IL‐12), a cytokine, regulates the immune system. High levels of IL‐12 can lead to chronic inflammation, exacerbate resistance to insulin, and contribute to type 2 diabetes. Also, link IR to acne vulgaris (AV), as it reduces tissue sensitivity to insulin, causing increased insulin levels and sebum production, which can contribute to acne development.AimTo explore the role of IL‐12 gene expression on IR in AV patients and to study the role of IL‐12 gene in the development of AV.Subjects and MethodsA case–control study was performed on 68 AV patients and 68 healthy controls. The biochemical analysis included fasting glucose, fasting insulin, (HOMA‐IR), and serum IL‐12 level. IL‐12 gene expression was performed by quantitative real‐time PCR for both two groups. In addition, folding change was calculated by using the standard 2–(∆∆Ct) method.ResultIL‐12 level, IL‐12 folding change, fasting insulin, and IR were all increased in acne patients. A highly significant linear correlation was found between IL‐12 folding change and both IL‐12 levels and IR. There is a substantial positive significant simple linear association between IL‐12 level and IL‐12 folding change, as well as IR and IL‐12 folding change, in moderate and severe acne.ConclusionIL‐12 gene has an important role in IR and the development of acne in AV patients.

Publisher

Wiley

Subject

Dermatology

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