Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia-Reference-Cited by-同舟云学术

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Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia

Published:2017-08-02 Issue:6 Volume:182 Page:927-930
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Varghese Abraham M.¹^ORCID,Rawstron Andy²,Newton Darren³,Tooze Reuben M.³,Munir Talha¹,Dickson Marion⁴,Doody Gina M.³,Hillmen Peter¹

Affiliation:

1. Department of Haematology; St. James's University Hospital; Leeds UK

2. Haematological Malignancy Diagnostic Service; St. James's University Hospital; Leeds UK

3. Leeds Institute of Cancer and Pathology; University of Leeds; Leeds UK

4. Immunoinflammation Therapy Area; GlaxoSmithKline; Stevenage UK

Publisher

Wiley

Subject

Hematology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bjh.14884/fullpdf

Reference10 articles.

1. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia;Byrd;The New England Journal of Medicine,2013

2. A novel spleen tyrosine kinase inhibitor Blocks c-Jun N-Terminal Kinase-Mediated gene expression in synoviocytes;Cha;Journal of Pharmacology and Experimental Therapeutics,2006

3. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia;Friedberg;Blood,2010

4. Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals;Herman;Blood,2010

5. Synthetic studies on novel Syk inhibitors. Part 1: synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives;Hisamichi;Bioorganic & Medicinal Chemistry,2005

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