Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions-Reference-Cited by-同舟云学术

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Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions

Published:2014-04-11 Issue:9 Volume:171 Page:2351-2363
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Aatsinki Sanna-Mari¹²,Buler Marcin¹²,Salomäki Henriikka³,Koulu Markku³,Pavek Petr⁴,Hakkola Jukka¹²

Affiliation:

1. Department of Pharmacology and Toxicology; Institute of Biomedicine; University of Oulu; Oulu Finland

2. Medical Research Center Oulu; Oulu University Hospital and University of Oulu; Oulu Finland

3. Department of Pharmacology, Drug Development and Therapeutics; Institute of Biomedicine; University of Turku; Turku Finland

4. Department of Pharmacology and Toxicology; Faculty of Pharmacy in Hradec Kralove; Charles University in Prague; Hradec Kralove Czech Republic

Publisher

Wiley

Subject

Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.12585/fullpdf

Reference43 articles.

1. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD;Amat;J Biol Chem,2009

2. Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes;Arpiainen;Toxicol Appl Pharmacol,2008

3. Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism;Buler;PLoS ONE,2012

4. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity;Canto;Nature,2009

5. Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5;Caton;J Endocrinol,2010

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