A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first‐line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin

Author:

Jones Robert1,Crabb Simon2,Chester John345,Elliott Tony6,Huddart Robert7,Birtle Alison8,Evans Linda9,Lester Jason4,Jagdev Satinder5,Casbard Angela10,Huang Chao1011,Madden Tracie‐Ann10,Griffiths Gareth210ORCID

Affiliation:

1. Beatson West of Scotland Cancer Centre University of Glasgow Glasgow UK

2. Southampton Clinical Trials Unit University of Southampton Southampton UK

3. Cardiff University Cardiff UK

4. Velindre Cancer Centre Cardiff UK

5. St. James's University Hospital Leeds UK

6. Christie Hospital NHS Foundation Trust Manchester UK

7. Institute of Cancer Research Sutton UK

8. Royal Lancaster Infirmary Lancaster UK

9. Weston Park Hospital SheffieldUK

10. Centre for Trials Research Cardiff University Cardiff UK

11. Hull York Medical School University of Hull Hull UK

Funder

Cancer Research UK

Publisher

Wiley

Subject

Urology

Reference28 articles.

1. Cancer Research UK.Bladder Cancer statistics reports for the UK 2016. Available at:http://www.cancerresearchuk.org/health‐professional/cancer‐statistics/statistics‐by‐cancer‐type/bladder‐cancer. Accessed January 2020

2. The global epidemiology of bladder cancer: a joinpoint regression analysis of its incidence and mortality trends and projection;Wong MC;Sci Rep,2018

3. Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Study

4. A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study.

5. Chemotherapy for bladder cancer: a United Kingdom practice survey;Egan PVB;J Clin Oncol,2008

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