Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells

Author:

Merkel Steven F.12ORCID,Andrews Allison M.12ORCID,Lutton Evan M.1,Mu Dakai3,Hudry Eloise345,Hyman Bradley T.345,Maguire Casey A.34,Ramirez Servio H.126

Affiliation:

1. Department of Pathology and Laboratory Medicine; The Lewis Katz School of Medicine at Temple University; Philadelphia Pennsylvania USA

2. Center for Substance Abuse Research; The Lewis Katz School of Medicine at Temple University; Philadelphia Pennsylvania USA

3. Department of Neurology; The Massachusetts General Hospital; Charlestown Massachusetts USA

4. NeuroDiscovery Center; Harvard Medical School; Boston Massachusetts USA

5. Alzheimer Research Unit; The Massachusetts General Hospital Institute for Neurodegenerative Disease; Charlestown Massachusetts USA

6. Shriners Hospitals Pediatric Research Center; The Lewis Katz School of Medicine at Temple University; Philadelphia Pennsylvania USA

Funder

National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA)

NIH/National Institute of Neurological Disorders and Stroke (NINDS)

The Shriners Hospitals for Children

American Brain Tumor Association

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Reference39 articles.

1. Astrocyte-endothelial interactions at the blood-brain barrier;Abbott;Nat. Rev. Neurosci.,2006

2. Adsorptive endocytosis mediates the passage of HIV-1 across the blood-brain barrier: evidence for a post-internalization coreceptor;Banks;J. Cell Sci.,1998

3. Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: role of envelope proteins and adsorptive endocytosis;Banks;J. Virol.,2001

4. The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice;Bell;J. Clin. Investig.,2011

5. Identification of the galactose binding domain of the adeno-associated virus serotype 9 capsid;Bell;J. Virol.,2012

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