Interim 2023/2024 Season Influenza Vaccine Effectiveness in Primary and Secondary Care in the United Kingdom

Author:

Whitaker Heather1ORCID,Findlay Beth2,Zitha Jana3ORCID,Goudie Rosalind4,Hassell Katie5,Evans Josie2,Kalapotharakou Panoraia3,Agrawal Utkarsh4,Kele Beatrix6ORCID,Hamilton Mark2,Moore Catherine7,Byford Rachel4,Stowe Julia5,Robertson Chris28,Couzens Anastasia7,Jamie Gavin4ORCID,Hoschler Katja6,Pheasant Kathleen7,Button Elizabeth4,Quinot Catherine5,Jones Tim7,Anand Sneha4,Watson Conall5,Andrews Nick5,de Lusignan Simon49,Zambon Maria6,Williams Christopher10,Cottrell Simon3,Marsh Kimberly2,McMenamin Jim2,Lopez Bernal Jamie5

Affiliation:

1. Statistics, Modelling and Economics Department UK Health Security Agency London UK

2. Clinical and Protecting Health Public Health Scotland Glasgow UK

3. Public Health Wales Communicable Disease Surveillance Centre and Vaccine Preventable Disease Programme Public Health Wales NHS Trust Cardiff UK

4. Nuffield Department of Primary Care University of Oxford Oxford UK

5. Immunisation and Vaccine Preventable Diseases Division UK Health Security Agency London UK

6. Respiratory Virus Unit UK Health Security Agency London UK

7. Wales Specialist Virology Centre Public Health Wales Microbiology, Cardiff, UHW Cardiff UK

8. Department of Mathematics and Statistics University of Strathclyde Glasgow UK

9. Research and Surveillance Centre Royal College of General Practitioners London UK

10. Public Health Wales Communicable Disease Surveillance Centre Public Health Wales NHS Trust Cardiff UK

Abstract

ABSTRACTBackgroundWe report 2023/2024 season interim influenza vaccine effectiveness for three studies, namely, primary care in Great Britain, hospital settings in Scotland and hospital settings in England.MethodsA test negative design was used to estimate vaccine effectiveness.ResultsEstimated vaccine effectiveness against all influenzas ranged from 63% (95% confidence interval 46 to 75%) to 65% (41 to 79%) among children aged 2–17, from 36% (20 to 49%) to 55% (43 to 65%) among adults 18–64 and from 40% (29 to 50%) to 55% (32 to 70%) among adults aged 65 and over.ConclusionsDuring a period of co‐circulation of influenza A(H1N1)pdm09 and A(H3N2) in the United Kingdom, evidence for effectiveness of the influenza vaccine in both children and adults was found.

Publisher

Wiley

Reference14 articles.

1. UK Health Security Agency “The Green Book; Chapter 19: Influenza. UKHSA Gateway Number 2020296 ” accessed 15 Feb 2024 https://www.gov.uk/government/publications/influenza‐the‐green‐book‐chapter‐19.

2. G.Smith A.McMahon andA.Strath “Seasonal Flu Immunisation Programme 2023/24: Confirmation of Adult Cohorts. 18 April 2023 ” Letter The Scottish Government accessed February 15 2024 https://www.sehd.scot.nhs.uk/cmo/CMO(2023)05.pdf.

3. World Health Organization (WHO) “Recommended Composition of Influenza Virus Vaccines for Use in the 2023–2024 Northern Hemisphere Influenza Season ” 24 February 2023 Meeting report Geneva: WHO accessed February 6 2023 https://www.who.int/publications/m/item/recommended‐composition‐of‐influenza‐virus‐vaccines‐for‐use‐in‐the‐2023‐2024‐northern‐hemisphere‐influenza‐season.

4. Public Health Wales “Public Health Wales Influenza Surveillance Report: Week 4 2024 ” accessed February 6 2024 https://phw.nhs.wales/topics/immunisation‐and‐vaccines/fluvaccine/weekly‐influenza‐and‐acute‐respiratory‐infection‐report/.

5. Public Health Scotland “Viral Respiratory Diseases (Including Influenza and COVID‐19) in Scotland Surveillance Report: 01 February 2024 ” accessed February 6 2024 https://www.publichealthscotland.scot/publications/viral‐respiratory‐diseases‐including‐influenza‐and‐covid‐19‐in‐scotland‐surveillance‐report/viral‐respiratory‐diseases‐including‐influenza‐and‐covid‐19‐in‐scotland‐surveillance‐report‐1‐february‐2024/.

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