In vitroand non-invasivein vivoeffects of the cannabinoid-1 receptor agonist AM841 on gastrointestinal motor function in the rat

Author:

Abalo R.12,Chen C.34,Vera G.12,Fichna J.35,Thakur G. A.6,López-Pérez A. E.27,Makriyannis A.8,Martín-Fontelles M. I.12,Storr M.3

Affiliation:

1. Área de Farmacología y Nutrición y Unidad Asociada al Instituto de Química Médica (IQM) y al Centro de Investigación de Alimentos (CIAL) del Consejo Superior de Investigaciones Científicas (CSIC); Universidad Rey Juan Carlos; Alcorcón Madrid Spain

2. Grupo de Excelencia Investigadora URJC-Banco de Santander-Grupo multidisciplinar de investigación y tratamiento del dolor (i+DOL); Alcorcón Madrid Spain

3. MedizinischeKlinik 2 der Ludwig-Maximilians Universität München; Munich Germany

4. Shanghai Tenth People's Hospital; School of Medicine; Tongji University; Shanghai China

5. Department of Biochemistry; Medical University of Lodz; Lodz Poland

6. Department of Pharmaceutical Sciences; Northeastern University; Boston MA USA

7. Unidad del Dolor; Servicio de Anestesiología; Hospital General Universitario Gregorio Marañón (HGUGM); Madrid Spain

8. Center for Drug Discovery; Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences; Northeastern Universtiy; Boston MA USA

Funder

Ministerio de Ciencia y Tecnología

Comunidad de Madrid

Crohn's and Colitis Foundation of Canada

National Institutes of Health

Publisher

Wiley

Subject

Gastroenterology,Endocrine and Autonomic Systems,Physiology

Reference48 articles.

1. Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases;Schicho;Can J Gastroenterol Hepatol,2011

2. The gastrointestinal pharmacology of cannabinoids: focus on motility;Abalo;Pharmacology,2012

3. Selective lack of tolerance to delayed gastric emptying after daily administration of WIN 55,212-2 in the rat;Abalo;Neurogastroenterol Motil,2009

4. The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212-2 on gastrointestinal motility in the rat;Abalo;Neurogastroenterol Motil,2010

5. Cannabinoid-induced delayed gastric emptying is selectively increased upon intermittent administration in the rat: role of CB1 receptors;Abalo;Neurogastroenterol Motil,2011

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