1. Division of Statistics and Scientific Computation and Section of Integrative Biology; University of Texas at Austin; Austin, Texas 78712 U.S.A.
2. The Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University; Baltimore, Maryland 21287 U.S.A.
3. Department of Family and Preventive Medicine; University of California; San Diego, La Jolla, California 92093 U.S.A.