Role of AT‐rich interaction domain 1A in gastric cancer immunotherapy: Preclinical and clinical perspectives

Author:

Zhang Xuemei1ORCID,Zhang Youzhi12ORCID,Zhang Qiaoyun2ORCID,Lu Mengyao1ORCID,Chen Yuan1ORCID,Zhang Xiaoyu3ORCID,Zhang Peng1ORCID

Affiliation:

1. Department of Oncology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China

2. School of Pharmacy Hubei University of Science and Technology Xianning China

3. Division of Gastrointestinal Surgery, Department of General Surgery, Huai'an Second People's Hospital the Affiliated Huai'an Hospital of Xuzhou Medical University Huaian China

Abstract

AbstractThe application of immune checkpoint inhibitor (ICI) using monoclonal antibodies has brought about a profound transformation in the clinical outcomes for patients grappling with advanced gastric cancer (GC). Nonetheless, despite these achievements, the quest for effective functional biomarkers for ICI therapy remains constrained. Recent research endeavours have shed light on the critical involvement of modified epigenetic regulators in the pathogenesis of gastric tumorigenesis, thus providing a glimpse into potential biomarkers. Among these regulatory factors, AT‐rich interaction domain 1A (ARID1A), a pivotal constituent of the switch/sucrose non‐fermentable (SWI/SNF) complex, has emerged as a promising candidate. Investigations have unveiled the pivotal role of ARID1A in bridging the gap between genome instability and the reconfiguration of the tumour immune microenvironment, culminating in an enhanced response to ICI within the landscape of gastric cancer treatment. This all‐encompassing review aims to dissect the potential of ARID1A as a valuable biomarker for immunotherapeutic approaches in gastric cancer, drawing from insights garnered from both preclinical experimentation and clinical observations.

Funder

Chinese Society of Clinical Oncology

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

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