Differences in change of post‐operative antioxidant levels between laser‐assisted lenticule extraction and femtosecond laser in situ keratomileusis

Author:

Chen Hung‐Chi123ORCID,Yang Shun‐Fa45ORCID,Lee Chia‐Yi467,Hsueh Yi‐Jen13,Huang Jing‐Yang5,Chang Chao‐Kai68ORCID

Affiliation:

1. Department of Ophthalmology Chang Gung Memorial Hospital Linkou Taiwan

2. Department of Medicine Chang Gung University College of Medicine Taoyuan Taiwan

3. Center for Tissue Engineering Chang Gung Memorial Hospital Linkou Taiwan

4. Institute of Medicine, Chung Shan Medical University Taichung Taiwan

5. Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan

6. Nobel Eye Institute Taipei Taiwan

7. Department of Ophthalmology, Jen‐Ai Hospital Dali Branch Taichung Taiwan

8. Department of Optometry Da‐Yeh University Chunghua Taiwan

Abstract

AbstractTo evaluate the change of total antioxidant capacity (TAC) and ascorbic acid (AA) between femtosecond laser in situ keratomileusis (FS‐LASIK) and laser‐assisted lenticule extraction (LALEX). A prospective non‐randomized study was conducted, and 33 and 75 eyes that had undergone FS‐LASIK or LALEX surgeries were enrolled, respectively. The tear films near corneal incisions were collected, and the concentrations of TAC and AA were determined. The generalized linear mixed model was adopted to calculate the adjusted odds ratio (aOR) with 95% confidence interval (CI) of TAC and AA between the two groups. The AA reduction was significant 1 month after the LALEX and FS‐LASIK procedures (both p < 0.05), and the decrement in AA level was significantly larger in the FS‐LASIK group compared to the LALEX group (p = 0.0002). In the subgroup analysis, the LALEX group demonstrated a lower decrement in TAC level in the individuals with dry eye disease (DED) than the FS‐LASIK group (p = 0.0424), and the LALEX group demonstrated a significantly lower AA decrement in the participants with high myopia (p = 0.0165) and DED (p = 0.0043). The LALEX surgery causes lesser AA decrement compared to FS‐LASIK surgery especially for the patients with DED.

Funder

Chang Gung Memorial Hospital

Ministry of Science and Technology, Taiwan

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

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