Affiliation:
1. School of Public Health Shanxi Medical University Taiyuan China
2. School of Pharmacy Shanxi Medical University Taiyuan China
3. Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University Taiyuan China
4. Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China
5. Third Clinical College Shanxi University of Chinese Medicine Jinzhong China
6. Department of Health Statistics and Epidemiology, School of Public Health Shanxi Medical University Taiyuan China
Abstract
AbstractIn recent years, an increasing number of observational studies have revealed an association between gut microbiota composition and psoriasis patients. However, whether this association reflects a causal relationship remains unclear. This study aimed to identify the causal relationship between gut microbiota and psoriasis through relevant research. In order to determine whether gut microbiota and psoriasis are causally related, we conducted a Mendelian randomization analysis using summary statistics from genome‐wide association studies (GWAS). As the exposure factor, we used summary statistics data from a GWAS study conducted by the MiBioGen Consortium, including 18,340 individuals with whole‐genome gut microbiota composition, and data from the FinnGen GWAS study on psoriasis, including 9267 patients and 364,071 controls as the disease outcome. Two‐sample Mendelian randomization analysis was subsequently performed with inverse variance weighted, MR‐Egger and weighted median, while sensitivity analyses were conducted to address heterogeneity and horizontal pleiotropy. The IVW results confirmed the causal relationship between certain gut microbiota groups and psoriasis. Specifically, family Veillonellaceae (OR = 1.162, 95% CI: 1.038–1.301, p = 0.009), genus Candidatus Soleaferrea (OR = 1.123, 95% CI: 1.011–1.247, p = 0.030) and genus Eubacterium fissicatena group (OR = 0.831, 95% CI: 0.755–0.915, p = 0.00016) showed significant associations. Sensitivity analysis did not reveal any abnormalities in SNPs. Currently, we have found some causal relationship between the gut microbiota and psoriasis. However, the study needs further RCTs for further validation.
Funder
ShanXi Science and Technology Department
National Natural Science Foundation of China
Subject
Cell Biology,Molecular Medicine