A pan‐cancer analysis of prognostic significance and immunological role of lysosomal‐associated membrane protein 3

Author:

Feng Xuefei1,Gao Lvye1,Shen Xinyuan1,Li Mingtai1,Wang Xiaohui1,Hao Yanlong1,Chen Jinyan1,Zhai Yuanfang1,Zou Binbin1,Yao Shangman2,Guo Yanlin1,Zhang Ling1ORCID

Affiliation:

1. Department of Pathology, Basic Medical Sciences Center Key Laboratory of Cellular Physiology of Shanxi Medical University Taiyuan China

2. School of Humanities and Social Sciences Shanxi Medical University Taiyuan China

Abstract

AbstractLysosomal dysfunction can drive carcinogenesis. Lysosomal‐associated membrane protein 3 (LAMP3), is a member of the Lysosome Associated Membrane Proteins and is involved in the malignant phenotype such as tumour metastasis and drug resistance, while the mechanisms that regulate the malignant progression of tumour remain vague. Our study aims to provide a more systematic and comprehensive understanding of the role of LAMP3 in the progression of various cancers by various databases.We explored the role of LAMP3 in pan‐cancer using The Cancer Genome Atlas (TCGA) and Genotype‐Tissue Expression (GTEx) database. Multiple online web platforms and software were used for data analysis, including HPA, TIMER, TISIDB, GEPIA, UALCAN, Kaplan–Meier plotter, DAVID and TIGER. The immunohistochemistry was used to quantify the LAMP3 and PD‐L1 expression levels in cancer.High LAMP3 expression was found in most cancers and differentially expressed across molecular and immune subtypes. The expression of LAMP3 was involved in the immune‐associated processes of Antigen processing and presentation, Th17 cell differentiation, Th1 and Th2 cell differentiation, and the immune‐associated pathways of T cell receptor and B cell receptor signalling pathways in most cancers. It also correlated with genetic markers of immunomodulators in various cancers. LAMP3 and PD‐L1 expression in BRCA and HNSC tissues was higher than that in corresponding adjacent normal tissues by immunohistochemistry. There is a significant correlation between the expression of LAMP3 and PD‐L1.Our study elucidates that LAMP3 has different expression patterns and genetic alteration patterns in different tumours. It is a potential biomarker for immune‐related cancer diagnosis, prognosis and efficacy prediction.

Funder

Shanxi Province Science Foundation for Youths

Shanxi Scholarship Council of China

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

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