Glutathione Protects the Developing Heart from Defects and Global DNA Hypomethylation Induced by Prenatal Alcohol Exposure

Author:

Jawaid Safdar12,Strainic James P.1,Kim Jun1,Ford Matthew R.,Thrane Lars2,Karunamuni Ganga H.1,Sheehan Megan M.12,Chowdhury Amrin13,Gillespie Caitlyn A.14,Rollins Andrew M.2,Jenkins Michael W.12,Watanabe Michiko1ORCID,Ford Stephanie M1ORCID

Affiliation:

1. From the Division of Pediatric Cardiology (SJ, JPS, GHK, MMS, AC, CAG, MWJ, MW, SMF) Department of Pediatrics The Congenital Heart CollaborativeRainbow Babies and Children’s HospitalCase Western Reserve University School of Medicine Cleveland OhioUSA

2. Department of Biomedical Engineering (SJ, MMS, AMR, MWJ) School of Engineering Case Western Reserve University Cleveland OhioUSA

3. Brecksville‐Broadview Heights High School(AC) Broadview Heights OhioUSA

4. Fisk University(CAG) Nashville TennesseeUSA

Funder

National Heart, Lung, and Blood Institute

American Heart Association

Publisher

Wiley

Subject

Psychiatry and Mental health,Toxicology,Medicine (miscellaneous)

Reference98 articles.

1. Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

2. Antioxidant activity of folic acid: From mechanism of action to clinical application;Atteia BM;FASEB Jl,2009

3. Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain

4. Folate-mediated one-carbon metabolism and neural tube defects: Balancing genome synthesis and gene expression

5. Beutler E, Duron 0 & Kelly B M. Improved method for the determination of blood glutathione;Beutler E;J Lab Clin Med,1963

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