Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology
Author:
Affiliation:
1. Global Research and Early Development Merck Serono SA; Geneva Switzerland
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jnc.12129/fullpdf
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4. First and second generation gamma-secretase modulators (GSMs) modulate amyloid-beta (Abeta) peptide production through different mechanisms;Borgegard;J. Biol. Chem.,2012
5. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain;De;Nature,1999
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