European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe

Author:

Garne Ester1ORCID,Loane Maria2,Tan Joachim3,Ballardini Elisa4,Brigden Joanna3,Cavero‐Carbonell Clara5,Coi Alessio6,Damkjær Mads17,Garcia‐Villodre Laura5,Gissler Mika89,Given Joanne2,Heino Anna8,Jordan Sue10,Limb Elizabeth3,Neville Amanda11,Rissmann Anke12ORCID,Santoro Michele6,Scanlon Ieuan10,Urhoj Stine Kjaer113ORCID,Wellesley Diana14,Morris Joan3

Affiliation:

1. Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital University Hospital of Southern Denmark Kolding Denmark

2. Faculty of Life and Health Sciences Ulster University Coleraine UK

3. Population Health Research Institute, St George's University of London London UK

4. Neonatal Intensive Care Unit, Paediatric Section, IMER Registry (Emilia Romagna Registry of Birth Defects), Department of Medical Sciences University of Ferrara Ferrara Italy

5. Rare Diseases Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region Valencia Spain

6. Unit of Epidemiology of Rare Diseases and Congenital Anomalies Institute of Clinical Physiology, National Research Council Pisa Italy

7. Department of Regional Health Research University of Southern Denmark Odense Denmark

8. Department of Knowledge Brokers THL Finnish Institute for Health and Welfare Helsinki Helsinki Finland

9. Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden

10. Faculty of Medicine, Health and Life Science Swansea University Swansea UK

11. Emilia Romagna Registry of Birth Defects and Center for Clinical and Epidemiological Research University of Ferrara, Azienda Ospedaliero‐Universitaria di Ferrara Ferrara Italy

12. Malformation Monitoring Centre Saxony‐Anhalt Medical Faculty Otto‐von‐Guericke‐University Magdeburg Magdeburg Germany

13. Section of Epidemiology, Department of Public Health University of Copenhagen Copenhagen Denmark

14. Faculty of Medicine and Wessex Clinical Genetics Service Princess Anne Hospital Southampton UK

Abstract

AbstractAimChildren with congenital anomalies often require surgery but data on the burden of surgery for these children are limited.MethodsA population‐based record‐linkage study in Finland, Wales and regions of Denmark, England, Italy and Spain. A total of 91 504 children with congenital anomalies born in 1995–2014 were followed to their tenth birthday or the end of 2015. Electronic linkage to hospital databases provided data on inpatient surgical procedures and meta‐analyses of surgical procedures were performed by age groups.ResultsThe percentage of children having surgery in the first year was 38% with some differences across regions and 14% also underwent surgery at age 1–4 years. Regional differences in age at the time of their first surgical procedure were observed for children with cleft palate, hydronephrosis, hypospadias, clubfoot and craniosynostosis. The children had a median of 2.0 (95% CI 1.98, 2.02) surgical procedures before age 5 years with children with oesophageal atresia having the highest median number of procedures (4.5; 95% CI 3.3, 5.8).ConclusionA third of children with congenital anomalies required surgery during infancy and often more than one procedure was needed before age 5 years. There was no European consensus on the preferred age for surgery for some anomalies.

Funder

Horizon 2020 Framework Programme

Publisher

Wiley

Subject

General Medicine,Pediatrics, Perinatology and Child Health

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