Affiliation:
1. Department of Gastroenterology, the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China
2. Department of Gastroenterology Ningbo First Hospital Ningbo 315010 China
3. Zhejiang Provincial Clinical Research Centre for Digestive Diseases Hangzhou 310003 China
Abstract
AbstractBackground and AimsThe association of serum uric acid (SUA) levels with liver‐related morbidity and mortality remains undetermined. Therefore, we aimed to explore the association of SUA levels with liver‐related morbidity and mortality.MethodsThe present cohort study included 459 619 adults from the UK Biobank. Multivariable Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of SUA levels with morbidity and mortality of overall liver disease. Mendelian randomization (MR) analyses were conducted to explore the underlying causality. A polygenic risk score was generated to assess whether there was a gene‐exposure interaction.ResultsDuring a median follow‐up of 12.6 years, 14 302 nonfatal and 609 fatal cases of overall liver disease were identified. Compared to individuals in the lowest quartile, the HRs (95% CI) of incident overall liver disease were 1.08 (1.02–1.14), 1.13 (1.07–1.20) and 1.44 (1.36–1.53) for individuals with SUA levels in quartiles 2, 3 and 4 respectively. Similarly, the HRs (95% CI) of liver disease‐associated mortality were 1.09 (0.78–1.52), 1.55 (1.14–2.13) and 1.96 (1.42–2.69) for individuals with SUA levels in quartiles 2, 3 and 4 respectively. The MR results did not support the causal association of SUA levels with liver disease. In addition, there was a significant modification effect of the polygenic risk score on the association of SUA levels with incident overall liver disease (pinteraction = .003).ConclusionsHigher SUA levels were significantly associated with an increased risk of overall liver disease morbidity and mortality.
Funder
National Natural Science Foundation of China
National Basic Research Program of China
Cited by
3 articles.
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