Bacteriophage‐based approach for treatment of urinary tract infections: a quick outlook

Author:

Grygorcewicz Bartłomiej12ORCID,Gliźniewicz Marta1ORCID,Jabłońska Joanna2ORCID,Augustyniak Adrian234ORCID,Olszewska Patrycja1ORCID,Wojciuk Bartosz5ORCID,Miłek Dominika1ORCID,Serwin Natalia1,Czajkowski Artur1ORCID,Cecerska‐Heryć Elżbieta12,Rakoczy Rafał2ORCID,Cymbaluk‐Płoska Aneta6ORCID

Affiliation:

1. Faculty of Pharmacy, Medical Biotechnology and Laboratory Medicine Pomeranian Medical University in Szczecin Szczecin Poland

2. Department of Chemical and Process Engineering, Faculty of Chemical Technology and Engineering West Pomeranian University of Technology, Szczecin Szczecin Poland

3. Chair of Building Materials and Construction Chemistry Technische Universität Berlin, Germany Berlin Germany

4. Institute of Biology University of Szczecin Szczecin Poland

5. Department of Immunology Diagnostics, Chair of Microbiology, Immunology and Laboratory Medicine Pomeranian Medical University in Szczecin Szczecin Poland

6. Department of Reconstructive Surgery and Gynecological Oncology Pomeranian Medical University in Szczecin Szczecin Poland

Abstract

Urinary tract infections (UTIs) are among the most common bacterial infections affecting millions worldwide. The increasing emergence of antibiotic‐resistant bacteria has become a serious concern in managing UTIs. Therefore, there is a growing interest in using bacteriophages as an alternative or adjunct therapy for UTIs. Bacteriophages are viruses that infect and kill bacteria, making them a promising tool for treating UTIs caused by antibiotic‐resistant bacteria. This article provides a quick outlook on using bacteriophages to treat UTIs. We summarize the current understanding of the biology of bacteriophages, the challenges associated with developing phage‐based therapies, and the promising results of several case reports and clinical trials. We also highlight the potential of phage therapy as a valuable tool in the fight against antibiotic‐resistant UTIs. This quick outlook on a bacteriophage‐based approach for treating UTIs offers a timely and informative summary of the current research in this field.

Funder

Narodowe Centrum Badań i Rozwoju

Publisher

Wiley

Subject

Microbiology (medical),General Medicine,Immunology and Allergy,Pathology and Forensic Medicine

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