Affiliation:
1. Department of Veterinary and Animal Science, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark
2. Copenhagen Wound Healing Center Bispebjerg University Hospital Copenhagen Denmark
3. Department of Orthopedic Surgery Herlev Hospital Herlev Denmark
Abstract
Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture‐related infection patient, all with staphylococci‐positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both Staphylococcus aureus and Staphylococcus epidermidis were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion.
Subject
Microbiology (medical),General Medicine,Immunology and Allergy,Pathology and Forensic Medicine
Cited by
1 articles.
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