Evaluation of the activated partial thromboplastin time assay for clinical monitoring of PEGylated recombinant factor VIII (BAY 94-9027) for haemophilia A

Author:

Gu J-M.1,Ramsey P.1,Evans V.1,Tang L.2,Apeler H.2,Leong L.1,Murphy J. E.2,Laux V.1,Myles T.1

Affiliation:

1. Hematology Research; US Innovation Center; Bayer HealthCare Pharmaceuticals; San Francisco CA USA

2. Biological Research; US Innovation Center; Bayer HealthCare Pharmaceuticals; San Francisco CA USA

Publisher

Wiley

Subject

Genetics (clinical),Hematology,General Medicine

Reference29 articles.

1. National Hemophilia Foundation. MASAC recommendation concerning prophylaxis (regular administration of clotting factor concentrate to prevent bleeding) http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=57&contentid=1007

2. Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia;Manco-Johnson;N Engl J Med,2007

3. Longer-acting factor VIII to overcome limitations in haemophilia management: the PEGylated liposomes formulation issue;Minno;Haemophilia,2010

4. Therapeutic antibody fragments with prolonged in vivo half-lives;Chapman;Nat Biotechnol,1999

5. PEGylated therapeutic proteins for haemophilia treatment: a review for haemophilia caregivers;Ivens;Haemophilia,2013

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