Vitamin B12 deficiency misdiagnosed as TTP: What can we learn from it?

Author:

Lämmle Bernhard123ORCID,Laemmle Alexander45

Affiliation:

1. Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz Germany

2. Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital University of Bern Bern Switzerland

3. Haemostasis Research Unit University College London London UK

4. Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital University of Bern Bern Switzerland

5. University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern Bern Switzerland

Abstract

The case report by Dwyre et al. shows that vitamin B12 deficiency may be misdiagnosed as acute thrombotic thrombocytopenic purpura. Together with similar observations, this underlines that acquired vitamin B12 deficiency—besides the inherited disorder of intracellular cobalamin metabolism, cbl C disease—should be listed as a separate entity of the thrombotic microangiopathies.Commentary on: Dwyre et al. Microangiopathic thrombocytopenia caused by vitamin B12 deficiency responding to plasma exchange. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19625.

Publisher

Wiley

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