Recurrent ischemic strokes and elevated CA125 levels in a patient with Meigs syndrome: A case report

Author:

Takahashi Hisashi1ORCID,Yasuda Rei1,Kubota‐Hanya Misaki1,Kitani Keisuke1,Yamashita Suguru2,Kuroboshi Haruo2,Honda Mizuki3,Imura Tetsuya3,Ohara Tomoyuki4ORCID,Kimura Tadashi5

Affiliation:

1. Department of Neurology, North Medical Center Kyoto Prefectural University of Medicine Kyoto Japan

2. Department of Obstetrics and Gynecology, North Medical Center Kyoto Prefectural University of Medicine Kyoto Japan

3. Department of Surgical Pathology, North Medical Center Kyoto Prefectural University of Medicine Kyoto Japan

4. Department of Neurology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan

5. Department of Neurology National Hospital Organization Maizuru Medical Center Kyoto Japan

Abstract

AbstractA 72‐year‐old woman developed left hemiparesis, and her initial magnetic resonance imaging (MRI) showed multiple acute ischemic lesions. Although she was treated with antithrombotic therapies, follow‐up MRI showed a recurrent small ischemic stroke. Her serum CA125 level was markedly elevated, and abdominal computed tomography (CT) and MRI showed a pelvic mass lesion with pleural effusions and ascites, suggesting malignant ovarian tumor associated with Trousseau's syndrome. However, the surgical resection specimens were pathologically diagnosed as benign ovarian fibroma and serous cystadenoma, and she was finally diagnosed as having Meigs syndrome. This case suggested that Meigs syndrome with elevated CA125 levels might play a role in the development of recurrent ischemic strokes.

Publisher

Wiley

Reference5 articles.

1. Meigs' and Pseudo-Meigs' syndrome

2. Meigs syndrome presenting with axillary vein thrombosis and lymphadenopathy: a case report;Iyer R;J Med Case Reports,2013

3. Elevated CA125 level associated with Meigs' syndrome: case report and review of the literature;Morán‐Mendoza A;Int J Gynecol Cancer,2006

4. Stroke in patients with common noncancerous gynecologic diseases: a multicenter study in Japan;Yamashiro K;Neurol Clin Pract,2023

5. Elevated CA125 is Related to Stroke Due to Cancer- Associated Hypercoagulation

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