ROS scavenger, N-acetyl-l-cysteine and NOX specific inhibitor, VAS2870 reduce platelets apoptosis while enhancing their viability during storage
Author:
Affiliation:
1. Blood Transfusion Research Center; High Institute for Research and Education in Transfusion Medicine; Tehran Iran
2. Australian Centre for Blood Diseases; Monash University; Melbourne Victoria Australia
Funder
Iranian blood transfusion organization and High Institute for Research and Education in Transfusion Medicine
Publisher
Wiley
Subject
Hematology,Immunology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/trf.15114/fullpdf
Reference37 articles.
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2. Platelet granule release is associated with reactive oxygen species generation during platelet storage: a direct link between platelet pro-inflammatory and oxidation states;Ghasemzadeh;Thromb Res,2017
3. Regulation of platelet activation and thrombus formation by reactive oxygen species;Qiao;Redox Biol,2018
4. Differential roles of the NADPH-oxidase 1 and 2 in platelet activation and thrombosis;Delaney;Arterioscler Thromb Vasc Biol,2016
5. The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner;Vara;Br J Pharmacol,2013
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